51例重症肌无力患者的临床与胸腺病理和电镜分析

Study on the Characteristics of Clinical Manifestations,Thymic Pathology and Ultrastructure of 51 Myasthenia Gravis Patients

目的分析胸腺增生与伴胸腺瘤的重症肌无力患者临床表现及其胸腺病理类型和超微结构特点。方法对51例MG患者的病例资料进行回顾性分析。按照胸腺瘤组和胸腺增生组,对临床症状、MG危象发生率、胸腺瘤WHO组织学分型、胸腺超微结构特点等各项指标进行对比。结果胸腺瘤组临床症状重、MG危象发生率高、术后MG症状改善程度差。结论胸腺瘤组MG患者病情重,WHO组织学分型对于区别良恶性肿瘤及预后有指导意义,胸腺超微结构特点的研究有助于澄清MG的发病机制。

Objective To analyze and compare the clinical characters,thymic pathology and ultrastructure of the MG patients with thymoma or thymic hyperplasia.Method A retrospective study was done on 51 patients.These patients were devided into two groups ：one group is thymoma and another is thymic hyperplasia.We evaluate the difference of clinical manifestations between the two groups such as clinical symptom,WHO classification,rate of MG crisis,hospital stay,ultrastructural character,etc.Result For the group of thymoma：the clinical manifestation is more severe,the rate of myasthenia crisis is higher and the prognosis is worse.Conclusion The patients with MG have following characteristics：Comparing with the patients with thymic hyperplasia,the clinical manifestation of the patients with thymoma is severe,the rate of myasthenia crisis is higher.The WHO classification of the thymoma is significative to distinct the benign and malignant tumor and estimate the prognosis.The characteristics of the thymic ultrastructure is beneficial to defecate the mechanism of MG.