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叶酸抗苯并[a]芘致突变作用的实验研究

Effect of folate acid to mutagenicity induced by benzo(a) pyrene
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摘要 目的:探讨叶酸抗苯并[a]芘致突变作用。方法:用不同浓度的叶酸(6.25、12.5、25、50μmol/L)对苯并[a]芘致鼠伤寒沙门氏菌TA98、TA100产生回复突变作用进行抗诱变实验。结果:不同浓度的叶酸对苯并[a]芘致TA98和TA100回复突变有抑制作用,经SPSS 17.0统计学分析,与阳性对照组比较,高剂量叶酸(25、50μmol/L)对TA98菌株抑制效果显著(P<0.05);叶酸各剂量组(6.25、12.5、25、50μmol/L)对TA100菌株均有极显著抑制效果(P<0.01)。结论:叶酸对苯并[a]芘具有抗诱变作用。 Objective： To investigate folate acid antagonizing mutagenesis to benzo（a） pyrene.Methods： The reformed Ames test was used in this study to investigate the antimutagenicity of folate acid to benzo（a）pyrene.Result： Different dosage groups of folate acid inhibited the reverse mutation of TA98 and TA100 induced by benzo（a）pyrene significantly.The antimutagenesis effect of high dosage（25,50 μmol/L） folate acid is significant in TA98（P0.05） strains and all dosage groups is extreme significant（P0.01） in TA100 strains comparing with the positive control group.All data was analysised using SPSS 17.0 for windows.Conclusion： Folate acid have effects of antagonizing mutagenesis to benzo（a）pyrene.
作者 占才贵 方敏 宫智勇 杨虎 周宁菱
机构地区 武汉工业学院食品科学与工程学院
出处 《食品科技》 CAS 北大核心 2011年第2期65-68,共4页 Food Science and Technology
基金 国家科技支撑计划项目(2009BADB9B02) 湖北省教育厅资助项目(D20091802)
关键词 叶酸 苯并[A]芘 致突变作用 folate acid benzo（a）pyrene mutagenesis
分类号 TS201.6 [轻工技术与工程—食品科学]
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参考文献15

  • 1Phillips DH. Polycyclic aromatic hydrocarbons in the diet. Mutat. Res,1999,443:139-147.
  • 2Phillips DH. Fifty years of beno(a)pyrene. Nature,1983,303:468-472.
  • 3Yang SK, Gelboin HV, Trump BF, et al. Metabolic activation of benzo(a)pyrene and binding to DNA in cultured human bronchus. Cancer Res,1977,37:1210-1215.
  • 4Buening MK, Wislocki PG, Levin W, et al. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a] pyrene7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta, 8alpha-dihydroxy-9alpha-epoxy-7,8,9,10 -tetrahydro benzo [a]pyrene.PNAS,1978,75: 5385-5361.
  • 5Telli-Karakoc F, Ruddock PJ, Bird DJ, et al. Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene. Mar Environ Res,2002,54:511-515.
  • 6Denissenko MF, Pao A, Tang M, et al. Preferential Formation of Benzo [a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53. Science,1996,274:430--432.
  • 7Giovannucci E. An Updated Review of the Epidemiological Evidence that Cigarette Smoking Increases Risk of Colorectal Cancer. Cancer Epidemiol. Biomarkers Prey, 2001,10:725-731.
  • 8Oakley GP. Eat right and take a multivitamin. N Engl J Med,1998,338:1060-1061.
  • 9Glynn SA, Albanes D. Folate and cancer: a review of the literature. Nutr Cancer,1994,22:101-119.
  • 10Maron DM, Ames BN. Revised methods for Salmonella mutagenicity test.Murat Res,1983,113:173-215.

二级参考文献30

  • 1Ifergan I, Shafran A, Jansen G, et al.Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression: A role for BCRP in cellular folate homeostasis. J Biol Chem, 2004,279:25527-25534.
  • 2Akoglu B, Milovic V, Caspary WF, et al. Hyperproliferation of homocysteinetreated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate. Eur J Nutr, 2004,43(2):93-99.
  • 3Carrier J, Medline A, Sohn KJ, et al. Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice. Cancer Epidemiol Biomarkers Prev, 2003,12:(11 Pt 1):1262-1267.
  • 4Kim YI. Role of folate in colon cancer development and progression. J Nutr, 2003,133:3731S-3739S.
  • 5Kim YI. Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer? Cancer Epidemiol Biomarkers Prev. 2004,13(4):511-519.
  • 6Jacob RA, Gretz DM, Taylor PC, et al. Moderate folate depletion increases plasma homocysteine and decreases lymphocytes DNA methylation in post-menopausal women. J Nutr, 1998,128:1204-1212.
  • 7Fenech M. The role of folic acid and vitamin B12 in genomic stability of human cells. Mut Res, 2001,475(1-2):57-67.
  • 8Kang SS, Wong PW, Norusis M. Homocysteinemia due to folate deficiency. Metabolism, 1987,36(5):458-462.
  • 9Melnyk S, Pogribna M, Miller BG, et al. Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer lett, 1999,146:35-44.
  • 10Blount BC, Mack MM, Wehr CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. PNAS, 1997,94:3290-3295

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