我院41例严重不良反应报告分析

Analysis of 41 Serious ADR Cases in Our Hospital

目的:了解严重药品不良反应(ADR)发生的特点和规律,促进ADR监测,为临床安全用药提供参考。方法:收集我院2009年1～12月报告的41例严重ADR病例,按ADR发生的关联性因素进行统计、分析与评价。结果:41例ADR报告中抗感染药所占比例最大(54.71%),其次为中药注射剂(15.09%)和神经系统用药(9.44%);ADR累及器官或系统主要为皮肤及其附件损害、全身性损害;29例(70.73%)ADR由静脉给药途径所致。结论:重视ADR监测工作,特别是抗感染药和中药注射剂的安全性监测;加强临床合理用药,以减少严重ADR的发生。

Objective：To investigate the characteristics and rules of serious adverse drug reactions （ADR） to pro- mote ADR monitoring and guidance of clinical practice. Method： From January 2009 to December 2009, 41 severe ADR cases were statistically analyzed in our hospital and evaluated based on the ADR causality judgment criteria. Result：Of the 41 ADR cases,anti-infective gents ranked the first （54.71%）and were followed by the traditional Chinese medicine injection （ 15.09% ） and then by the nervous system agents （9.44%）. The systems or organs damaged by ADRs were lesions of skin and its appendage, and the systemic disorders. 29 ADR cases （70.73%） were induced by the intravenous drip. Conclusion：Great importance should be attached to the safe monitoring of antibiotics and traditional Chinese medicine injection, and the rational drug use should be improved to guard against severe ADRs.