标准化药物治疗对不稳定型心绞痛患者血清对氧磷脂酶-1活性的影响

The influence of standard therapy on serum paraoxonase activity in patients with unstable angina

目的:研究接受标准化药物治疗的不稳定型心绞痛患者血清对氧磷脂酶-1(PON1)活性的演变规律,评价标准化药物治疗对不稳定型心绞痛患者血清PON1活性的影响和意义。方法:对2008年7月-2009年12月在中山大学附属第一医院住院的80例不稳定型心绞痛患者进行标准化药物治疗,于治疗后的第1日、第5日、第10日和第15日检测患者血清PON1的活性;选取华南理工大学医院体检中心进行健康体检者50名作为健康对照组。结果:不稳定型心绞痛组第1日血清PON1活性明显低于健康对照组[(87±3)μmol/(min.ml)对比(105±8)μmol/(min.ml),P<0.05)],该组患者治疗后第1日、第5日PON1活性比较差异无统计学意义。不稳定型心绞痛组患者PON1活性表现出显著的提升作用开始于第10日,从第1日的(87±3)μmol/(min.ml)到第10日的(92±5)μmol/(m in.ml),再到第15日的(95±7)μmol/(min.ml)(P<0.05)。结论:接受标准化药物治疗的不稳定型心绞痛患者血清PON1活性升高,其活性的演变可能与其抗动脉粥样硬化作用有关。

Objective：To monitor the serum paraoxonase-1（PON1） activity in patients with unstable angina during standard therapy for evaluation of the influence and implication of standard therapy on serum PON1 activity.Methods：Eighty patients with unstable angina were enrolled,while 50 healthy subjects enrolled as healthy controls.The serum PON1 activity was tested at baseline and on 1st,5th,10th and 15th day.Results：Baseline PON1 activity in patients with unstable angina was significantly lower than that in controls[（87±3）μmol/（min· ml）vs（105±8）μmol/（min·ml）,P0.05],while no significant difference was observed on 1st and 5th day.Beneficial effect of standard therapy on PON1 activity was revealed on 10th and 15th day,with a weak but significant elevation[1st day：（87±3）μmol/（min·ml）;10th day：（92±5）μmol/（min· ml）;15th day：（95±7）μmol/（min· ml）,P 0.05]. Conclusion：The PON1 activity increases after standard therapy in patients with unstable angina,which may be responsible for its anti-athero effect.