儿童重型再生障碍性贫血外周血T淋巴细胞亚群的分析

A study on T-cell subgroup in peripheral blood of children with severe aplastic anemia

目的:探讨儿童重型再生障碍性贫血(SAA)的免疫学发病机制。方法:采用流式细胞仪检测20例SAA初诊患儿和20例骨科手术儿童(对照组)外周血做淋巴细胞表型分析。结果:CD3+在SAA组为(72.79±8.49)%,对照组为(64.41±11.26)%,差异有统计学意义(P<0.05),CD8+分别为(32.89±8.59)%,(22.87±8.77)%,差异有统计学意义(P<0.01),CD4+/CD8+比值分别为(1.06±0.46),(1.79±0.76),差异有统计学意义(P<0.01),CD2+5分别为(9.95±5.80)%,(7.13±1.16)%,差异有统计学意义(P<0.05),CD4+%、CD(16+56)+%与对照组差异无统计学意义(P>0.05)。结论:SAA患儿存在T淋巴细胞免疫功能的紊乱。

Objective To explore the immunological pathogenesis of severe aplastic anemia （SAA） in children. Method The T - cell subgroup in perigheral blood of 20 children with severe aplastic anemia （SAA group） and 20 children with orthopedic operation （the con- trol group） were determined by flow cytometer （FCM）. Results SAA group had higher levels of C D;, CD8＋ and CD2＋ T - cell, a lower ratio of CD4＋/CD0＋ compared to the control group. Conclusion The derangement of T - cell immunity exists in children with severe aplastic anemia.