继发性磺脲类药物失效患者IA-2抗体与胰岛β细胞功能关系分析

Correlation between protein tyrosine phosphatase-like IA-2 autoantibody and islet β-cell function in secondary sulfonylureas failure

目的:探讨IA-2抗体对继发性磺脲类药物失效的患者早期诊断和干预的作用。方法:测定173例继发性磺脲类药物失效的2型糖尿病患者的酪氨酸磷酸酶抗体(IA-2抗体),测定空腹及餐后胰岛素和C肽水平,评估胰岛β细胞功能。结果:体质指数、谷氨酸脱羧酶抗体(GAD抗体)浓度,胰岛素抵抗指数及糖负荷后30min胰岛素曲线下面积等指标在IA-2抗体阳性组与阴性组之间差异有统计学意义。结论:在糖尿病患者中早期测定IA-2、GAD等相关抗体对诊断分型,早期采用保护残存胰岛β细胞功能的治疗方法和对其预后的判定有重要意义。

Objective To investigate the effect of protein tyrosine phosphatase-like IA-2 autoantibody （IA- 2A） in type 2 diabetes mellitus patients with secondary sulfonylureas failure. Methods IA-2A was assayed in 173 type 2 diabetes mellitus patients with secondary sulfonylureas failure, fasting and postprandial insulin and C peptide were determined for evaluating the islet β-cell function. Results There were significant differences in the body mass index,dosage of glutamic acid decarboxylase antibody, insulin resistance index, and the area under curve of insulin for the first 30min in oral glucose tolerance test between the IA-2A positive and negative groups. Conclusion The combination of islet autoantibody examination is very important for early diagnosis and treatment.