期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抑癌基因DOC-1及其与肿瘤关系的研究进展

下载PDF
导出
摘要 口腔癌缺失基因（Deleted in oral cancer-1，DOC-1）是美国哈佛大学牙医学院口腔癌分子生物学实验室Todd等在仓鼠正常口腔上皮细胞中克隆出的-个候选抑癌基因．通过调控细胞周期而抑制细胞增殖．是一个进化上高度保守、显示杂合性缺失和在恶性角化细胞中表达明显消失的基因，与口腔癌的发病机理联系密切，本文将近年来有关DOC-1基因的研究成果综述如下。
作者 娄思园 生秀杰
机构地区 广州医学院第三附属医院妇产科研究所妇科二区
出处 《实用医学杂志》 CAS 北大核心 2011年第4期696-698,共3页 The Journal of Practical Medicine
基金 广州市教育局立项科研项目(编号:61052)
关键词 候选抑癌基因 DOC-1 肿瘤 抑制细胞增殖 口腔上皮细胞 美国哈佛大学 分子生物学 杂合性缺失
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献26

  • 1Todd R,McBride J,Tsuji T,et al.Deleted in oral cancer-1 (doc-1),a novel oral tumor suppressor gene[J].FASEB J,1995,9(13):1362-1370.
  • 2Tsuji T,Duh F M,Latif F,et al.Cloning,mapping,expression,function,and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene doc-1[J].J Biol Chem,1998,273(12):6704-6709.
  • 3Kohno Y,Patel V,Kim Y,et al.Apoptosis,proliferation and p12(doc-1) profiles in normal,dysplastic and malignant squamous epithelium of the Syrian hamster cheek pouch model[J].Oral Oncol,2002,38(3):274-280.
  • 4Shintani S,Ohyama H,Zhang X,et al.p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein[J].Mol Cell Biol,2000,20(17):6300-6307.
  • 5Cwikla S J,Tsuji T,McBride J,et al.doc-1-mediated apoptosis in malignant hamster oral keratinocytes[J].J Oral Maxillofac Surg,2000,58(4):406-414.
  • 6Sherr C J.Cancer cell cycles[J].Science,1996,274(5293):1672-1677.
  • 7Shintani S,Mihara M,Nakahara Y,et al.Expression of cell cycle control proteins in normal epithelium,premalignant and malignant lesions of oral cavity[J].Oral Oncol,2002,38(3):235-243.
  • 8Tsuji T,Ibaragi S,Shima K,et al.Epithelial-mesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth[J].Cancer Res,2008,68(24):10377-10386.
  • 9Kusk M,Ahmed R,Thomsen B,et al.Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins[J].Mol Cell Biochem,1999,191(1-2):51-58.
  • 10Zolochevska O,Figueiredo M L.Cell cycle regulator cdk2ap1 inhibits prostate cancer cell growth and modifies androgen-responsive pathwayfunction[J].Prostate,2009,69(14):1586-1597.

二级参考文献35

  • 1Moroco JR, Solt DB, Polverini PJ. Sequential loss of suppressor genes for three specific functions during in vivo carcinogenesis[J]. Lab Invest, 1990,63(3):298-306.
  • 2Todd R, McBride J, Tsuji T, et al. Deleted in oral cancer-1(doc-1), a novel oral tumor suppressor gene[J]. Faseb J, 1995,9(13):1362-1370.
  • 3Shintani S, Ohyama H, Zhang X, et al. p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein [J]. Mol Cell Biol, 2000,20(17):6300-6307.
  • 4Tsuji T, Duh FM, Latif F, et al. Cloning, mapping, expression,function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1 [J]. J Biol Chem, 1998,273( 12):6704-6709.
  • 5Todd R, Wong DT. DNA hybridization arrays for gene expression analysis of human oral cancer [J]. J Dent Res, 2002,81(2):89-97.
  • 6Sherr CJ. Cancer cell cycles [J]. Science, 1996,274(5293): 1672-1677.
  • 7Shintani S. Mihara M, Nakahara Y, et al. Expression of cell cycle control proteins in normal epithelium, premalignant and malignant lesions of oral cavity[J]. Oral Oncol,2002,38(3):235-243.
  • 8Hu MG, Hu GF, Kim Y, et al. Role of p12 (CDK2-AP1) in transforming growth factor-betal-mediated growth suppression[J]. Cancer Res, 2004,64(2):490-499.
  • 9Amann E, Ochs B, Abel KJ. Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli[J]. Gene, 1988,69(2):301-315.
  • 10Davies AH, Jowett JB, Jones IM. Recombinant baculovirus vectors expressing glutathione-S-transferase fusion proteins [J]. Biotechnology (NY), 1993,11(8):933-936.

共引文献14

实用医学杂志
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部