摘要
目的探讨Bcl-2的表达与甲状腺癌的发生、发展及预后的关系。方法应用免疫组化方法,以单克隆抗体鼠抗人Bcl-2标记77例甲状腺癌、58例甲状腺腺瘤、40例癌旁甲状腺组织和28例正常甲状腺组织。观察不同甲状腺组织中Bcl-2的表达,并比较其阳性率。结果 Bcl-2阳性反应见于甲状腺癌、甲状腺腺瘤及癌旁甲状腺组织。在甲状腺癌组织中Bcl-2阳性率为45.5%,高于甲状腺腺瘤组织(22.4%)(P=0.006)、癌旁甲状腺组织(17.5%)(P=0.003)和正常甲状腺组织(0)(P=0.000)。甲状腺未分化癌和滤泡状癌组织中Bcl-2的阳性率明显增高。存在淋巴结转移和临床Ⅲ、Ⅳ期病例中,Bcl-2的阳性率明显增高。结论 Bcl-2过量表达可能与甲状腺肿瘤的发生有关,癌组织中Bcl-2的表达可作为甲状腺癌预后的参考指标。
Objective To investigate the expression of suppressor gene Bcl-2 in thyroid tumors and its relationship to the oncogenesis,development and prognosis of the tumor.Methods The Expression of Bcl-2 was analyzed by immunohistochemical method in the tissues from 77 thyroid carcinomas,58 thyroid adenomas.40 thyroid tissues adjacent to cancer and 28 normal thyroid tissues.The positive expression rates in the different thyroid tissues were compared. Results Bcl-2 was expressed in 45.5% of the thyroid carcinoma,22.4% of the thyroid adenoma,17.5% of the thyroid tissues adjacent to cancer and non in normal thyroid tissues.The positive expression rate of Bcl-2 in the thyroid carcinoma was significantly higher than that in the thyroid adenoma（P=0.006）,thyroid tissues adjacent to cancer（P=0.003）and normal tissues（P=0.000）.In thyroid carcinoma,undifferentiated carcinoma,follicular carcinoma,carcinoma with positive lymph nodes,and tumors with stage Ⅲand Ⅳ disease had significantly higher expression of Bcl-2.Conclusion The overexpression of Bcl-2 may be related to the oncogenesis and development of thyroid tumor.Bcl-2 might be a possible prognostic factor of thyroid cancer.
出处
《中国实用医药》
2011年第2期17-18,共2页
China Practical Medicine
