复方硫磺凝胶的制备及临床应用

Preparation and clinical application of the gel of sulfur

目的研制复方硫磺凝胶,观察其临床应用效果。方法以卡波姆940为凝胶材料制备复方硫磺凝胶,建立质量控制方法;建立治疗组应用于50例疥疮患者,以硫磺软膏为对照组应用于40例疥疮患者,观察治疗效果。结果制备的凝胶均匀细腻,分散性好,建立的分析方法不受辅料的干扰,该制剂治疗组50例患者全部治愈,无一例发生任何不良反应。结论该制剂配制简便,质量可控,疗效可靠,有推广价值。

Objective To develop the gel of compound sulfur and observe the clinical effect of the gel. Methods The gel of compound sulfur was prepared by Carbopol-940 as the gel stroma,and the method of quality control was built up.52 cases with scabies were treated by the gel of compound sulfur while 40 cases were treated by the ointment of sulfur as control group. Results The gel of compound sulfur were exquisite and easy dispersions. The content deitective method was not be disturbed by the supplementary material. All of cases with scabies were cured by the gel of compound sulfur. No side-effect was found in the gel group. Conclusion The preparation was simple and stable.The gel is suitable to the clinical need,it is worthy to develop in clinic.