替罗非班联合急诊冠脉介入术治疗急性ST抬高性心肌梗死的临床观察被引量：4

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摘要目的探讨早期应用替罗非班联合急诊经皮冠脉介入治疗术(PCI)治疗急性心肌梗死(AMI)患者的疗效和临床预后。方法所有确诊ST段抬高性心肌梗死(STEMI)并于发作6h内行急诊PCI手术患者120例,随机分为A组和B组,各60例,两组均给予急诊PCI术、氯吡格雷、阿司匹林,A组另给予替罗非班静脉内使用,观察两组术后即刻靶血管TIMI血流分级、术后心电图改变(ST段回落幅度)、术后30d内心脏不良事件(MACE)及出血事件发生率情况。结果 A组PCI术后即刻靶血管TIMI血流分级明显高于B组,使用替罗非班治疗期间,A、B组出血事件及血小板减少症发生率比较,差异无统计学意义(P>0.05),A组术后ST段回落幅度较B组明显、30d内MACE发生率明显低于B组。结论在阿司匹林、氯吡格雷抗血小板治疗的基础上,ACS患者急诊PCI术中应用替罗非班比单纯PCI术及常规药物治疗,能进一步改善心肌灌注,从而改善预后。

作者刘海峰房志华

机构地区吉林省四平市中心人民医院

出处《中国实用医药》 2011年第2期151-153,共3页 China Practical Medicine

关键词替罗非班经皮经腔冠状动脉介入急性心肌梗死

分类号 R542.22 [医药卫生—心血管疾病]

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