2005-2009年浙江省天台县肾综合征出血热监测分析

Analysis of the surveillance data on hemorrhagic fever with renal syndrome in Tiantai county, Zhejiang province from 2005 to 2009

目的探讨天台县肾综合征出血热(HFRS)的流行特征和发展趋势,以制定有针对性的防制措施。方法人间疫情流行病学调查,采用间接免疫荧光法检测患者及健康人群血清抗体;宿主动物带病毒调查,采用直接免疫荧光法检测鼠肺汉坦病毒(HV)抗原。结果 2005-2009年全县累计报告HFRS病例181例,年平均发病率6.39/10万;男女发病之比为2.42∶1(128/53),以农民发病为主,占86.74%;室内鼠密度平均为2.10%,野外为5.76%,总鼠密度为4.87%,鼠带病毒率平均为7.48%;患者血清阳性率为77.70%。结论天台县是以姬鼠型为主的混合型HFRS疫区,需要进一步加大监测和预防力度。

Objective To study the epidemiological charactristics of hemorrhagic fever with renal syndrome（HFRS） in Tiantai county for the development of the strategies specific to the prevention and control of the epidemic. Methods Epidemiological investigation into the epidemic situation among human population was conducted by means of the indirect immunofluorescence assay （IFA） for the detection of serum antibody in patients and healthy population. The virus-carrying state of the host animals was determined by Hantaan virus antigen detection with the direct immunofluorescence assay. Results A total of 181 HFRS cases was reported with an average annual incidence rate of 6.39/105 in Tiantai county from 2005-2009. There was an incidence ratio of 2.42∶1 for male and female patients, with peasants affected predominantly accounting for 86.74%. The total density of rodents was 4.87% with an average indoor rodent density of 2.10% and an outdoor one of 5.76%. The average virus-carrying rate of rodents was 7.48% and the serum positive rate of patients was 77.70%. Conclusion Tiantai is a mixed HFRS epidemic area, with the Apodemus-type dominant. Greater efforts need to be made in the surveillance and prevention of the epidemic.