不同剂量阿托伐他汀钙治疗不稳定型心绞痛临床观察

The clinical investgation of different doses of Atorvastatin in unstable angina pectoris

目的观察不同剂量阿托伐他汀钙治疗不稳定型心绞痛(UAP)的疗效。方法将180例UAP患者随机分为治疗组和对照组各90例,对照组采用常规治疗,同时给予阿托伐他汀钙10mg/d,治疗组在常规治疗基础上加用阿托伐他汀钙至20mg/d,连用12周,观察两组患者临床疗效、心电图及血脂的变化。结果治疗组心绞痛总有效率92.2%,对照组心绞痛总有效率80.2%,两组比较差异有统计学意义(P<0.05);治疗组心电图总有效率92.2%,对照组心电图总有效率82.2%,两组比较差异有统计学意义(P<0.05);两组治疗前后血脂下降差异有统计学意义,治疗组下降更为明显(P<0.01)。结论较大剂量阿托伐他汀钙能有效改善UAP患者的症状、心电图和降低血脂,是治疗UAP安全有效的药物。

Objective To investigate the effect of different doses of Atorvastatin in unstable angina pectoris（UAP）.Methods In this trial of 12 weeks,180 patients diagnosed unstable angina pectoris were assigned randomly to the control group and the treatment group 90 respectively.In the control groups,90 patients accepted conventional treatments and Atorvastatin 10 mg daily,while in the treatment groups 90 patients accepted conventional treatment and Atorvastatin 20mg daily.The clinical effects,ECG and lipids were recored.Results The total effective rate of chest allevation in treatment group was 92.2%and ECG improvement was 92.2%;while the total effective rate of chest allevation in control group was82.2%and ECG improvement was 80.2%,there was a statistical significent difference（P0.01） Conclusion Larger doses Atorvastatin are effective in improving symptoms of unstable angina and therefore are very effective in treating unstable angina.