加减滋癸汤对肝肾阴虚型多囊卵巢综合征高雄激素血症的影响

Incites the last of the ten Heavenly Stems soup to add and subtract to the hepatorenal Yin deficient multi-pouch ovary syndrome high testosterone hormone blood's sickness influence research

目的观察加减滋癸汤对肝肾阴虚型多囊卵巢综合征高雄激素血症的疗效。方法采用随机对照的方法将66例辨证为肝肾阴虚型多囊卵巢综合征患者分为中药治疗组和西药对照组(各33例)。中药组口服加减滋癸汤;西药组口服达英-35(Diane-35)。观察治疗前、治疗停药后患者第1、6个月血清性激素、多毛、痤疮的变化。结果①治疗前后两组促卵泡激素(FSH)无明显变化,治疗停药1个月经周期后两组患者促黄体激素(LH)、睾酮(T)、LH/FSH比值均较治疗前降低,有统计学意义(P<0.01),停药6个月经周期后,中药组与治疗前比较仍下降明显(P<0.01),西药组恢复到治疗前水平(P>0.05)。②治疗停药1个月经周期后两组痤疮比治疗前均明显改善,有统计学意义(P<0.05),停药6个月经周期后,中药组较治疗前仍明显改善(P<0.05),西药组恢复到治疗前状态(P>0.05)。③两组治疗前后多毛均无明显变化(P>0.05)。结论加减滋癸汤可有效改善肝肾阴虚型多囊卵巢综合征高雄激素血症情况。

Objective To evaluate the officacy of Zi Kui Decoction in polycystic ovary with liver-kidney yin deficiency syndrome high testostrone hormone blood＇s sickness.Methods 66 poiycystic ovary patients with liver-kidney yin deficiency syndrome were enrolled.Thirty-three patients were divided into the group therapied by modified Zi Kui Decoction（treatment group） by randomized controlled method,while the other thirty-three patients were divided into the group therapied by Diane-35（controlgroup）.The change of their serum levels of sex hormones、pilosity、acne were observed before treatment of at the first menstruation menstrual cycle and the sixth menstruation menstrual cycle after treatment.Results ①FSH did not have significand change before and after treatment;treatment of a menstrual cycle after stopping the two groups of luteinizing hormone（LH）,testosterone（T）,LH/FSH（follicle stimulating hormone） ratio lower than that before treatment,there was significance（P 0.01）,affer six menstrual cycles,the Chinese medicine group is still down significantly（P 0.01）,western medicine group returned to baseline level（P 0.05）.②Treatment of a menstrual cycle after stopping the two grous of acne obviously change better than that before treatment,affer six menstrual cycles,the Chinese medicine group is still obviously change for the better（P 0.05）,western medicine group returned to baseline level（P 0.05 ）.③ Pilosity did not have significant change before and after treatment.Conclusion Modified Zi-Kui Decoction can be effectively change better polycystic ovary with liver-kidney yin deficiency syndrome high testosterone hormone blood＇s sickness.