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干扰程序性死亡分子1及其配体信号通路的免疫治疗 被引量：2

A therapeutic strategy of targeting PD1/PDL signal pathway
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摘要 程序性死亡分子1(programmed death-1,PD1)及其配体(programmed death ligand,PDL)属于B7家族的共刺激分子,介导免疫反应的负性调节信号,在肿瘤发生、病毒感染以及自身免疫病中都发挥了特异性的调节作用。利用PD1/PDL1信号途径调节机体的免疫应答从而达到免疫治疗的目的,该文就此展开综述。 PD1（programmed death-1,PD1）and PDL1（programmed death ligand-1,PDL1） are members of co-stimulating molecules of B7 superfamily.PDL1 binds to PD-1,which mainly expresses on the activated T cells,mediates the negative modulating signals.Interfering the PD1/PDL signal pathway regulates the immunological responses,which could be used as a therapeutic strategy for cancer,viral infection and auto-immune diseases.In this paper,we reviewed the current progress of the associated research.
作者 汪龚泽 刘朝奇
机构地区 三峡大学分子生物学研究所
出处 《生命科学》 CSCD 北大核心 2011年第1期86-89,共4页 Chinese Bulletin of Life Sciences
基金 湖北省自然科学基金项目(2008CDB118)
关键词 PD1 PDL1 免疫调节 免疫治疗 PD1 PDL1 immuno-regulation immunotherapy
分类号 R392.11 [医药卫生—免疫学]
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参考文献15

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同被引文献22

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生命科学
2011年 第1期

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