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单个肿瘤细胞测序研究进展 被引量：1

Progress in sequencing single cancer cell
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摘要 肿瘤是机体在各种致癌因素作用下,遗传物质受损导致特定细胞失去对正常生长调控,引起其克隆性异常增生而形成的恶性赘生物。随着单细胞分离技术及单细胞测序技术日益成熟,单个肿瘤细胞全基因组测序已成为肿瘤研究的一个崭新的领域。该文就对单个肿瘤细胞的获取及单个肿瘤细胞测序研究进展进行综述。 Malignant neoplasm is a class of diseases,in which a cell,or a group of cells display uncontrolled growth.With the development of the technology of single-cell separation and sequence,sequencing single tumor cell has become a new area of cancer research.We review the proceedings on sequencing and obtaining for single tumor cell.
作者 吴松 蔡志明
机构地区 北京大学深圳医院泌尿外科 安徽医科大学
出处 《生命科学》 CSCD 北大核心 2011年第1期135-138,共4页 Chinese Bulletin of Life Sciences
基金 国家高技术研究发展计划“(863”计划)(2006AA02A302)
关键词 肿瘤 单个肿瘤细胞分离 单个肿瘤细胞测序 tumor separating single tumor cell sequencing single cancer cell
分类号 R73-3 [医药卫生—肿瘤]
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参考文献21

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同被引文献16

  • 1Blainey PC, Quake SR. Dissecting genomic diversity, one cell at a time[J]. Nat Methods, 2014, 11(1): 19-21.
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  • 9Ni X, Zhuo M, Su Z, et al. Reproducible copy number variation patterns among single circulating tumor cells oflung cancer patients[J]. Proc Natl Acad Sci U S A, 2013, 110(52): 21083-21088.
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生命科学
2011年 第1期

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