亚甲蓝在保乳术前哨淋巴结活检中的应用

Application of methylene blue in sentinel lymph node biopsy in breast conservative therapy of breast cancer

目的 探讨亚甲蓝染色在乳腺癌保乳术前哨淋巴结活检（SLNB）中的应用价值.方法 55例临床Ⅰ～Ⅱ期乳腺癌患者,行亚甲蓝染色定位前哨淋巴结（SLN）,SLNB并腋窝淋巴结清扫（ALND）,对全部的SLN和腋窝淋巴结行病理检查并分析结果.结果 55例中成功检出SLN 52例,检出率95%,SLNB的灵敏度为100%（20/20）,准确率为93%（52/55）,假阴性率为5%（1/20）,假阳性率为0.结论 亚甲蓝染色是乳腺癌前哨淋巴结活检的可靠方法,SLNB是一种简便、安全的检测技术,可用于了解腋窝淋巴结的状况.

Objective To explore the clinical value of methylene blue in sentinel lymph node biopsy （ SLNB） in breast conservative therapy of breast cancer. Methods 55 patients performed sentinel lymph node biopsy（ SLNB）in were analyzed,with breast conservative therapy of breast cancer in clinical stage Ⅰ-Ⅱ. The mapping procedures and SLNB were performed using subareolar injection of Methylene blue dye,followed by the axillary lymph node dissection（ALND）. All of the SLN and ALN were evaluated pathologically after the operations. Results Among 55 cases ,52 cases were checked out sentinel lymph node and the positive rate was 95% （52/55）. The axillary status was 100% accurately predicted by SLNs;Sensitivity in this group was 93% （52/55） ;False negative rate was 5% （1/20）;False positive rate was 0. Conclusion Methylene blue dye is a reliable method for sentinel lymph node biopsy. SLNB is a simple and safe technic, which helps to reveal the state of the axillary lymph nodes.