黄芪不同有效部位对糖尿病模型大鼠血清胰岛素、脂联素的影响

Effect of Astragali Radix Active Ingredients on Serum Insulin and Adiponectin in Diabetes Rats

目的:探讨黄芪黄酮、黄芪多糖、黄芪皂苷3种有效部位对糖尿病大鼠血糖、血清胰岛素和脂联素的影响。方法:按STZ 52 mg.kg-1体重腹腔注射SD大鼠诱导糖尿病模型,分别给予黄芪黄酮、黄芪多糖、黄芪皂苷进行干预,给药剂量均相当于黄芪生药量6.3 g.kg-1。观测30 d,血糖仪检测血糖,ELISA法检测血清胰岛素、血清脂联素。结果:糖尿病模型大鼠血糖水平升高(P<0.05),血清胰岛素、脂联素水平下降(P<0.05)。黄芪黄酮可明显干预上述变化(P<0.05);黄芪多糖与黄芪皂苷虽略改善糖尿病模型大鼠的血糖、血清胰岛素、血清脂联素的水平,但未见统计学差异。结论:黄芪有效部位可影响糖尿病模型大鼠血糖、血清胰岛素和脂联素水平的变化,黄芪黄酮作用最为显著。

Objective：This study was designed to evaluate the effect of three active ingredients of Astragali Radix,namely a Astragalus flavonoids,polysaccharides,and astragalosides,on blood glucose,serum insulin and adi-ponectin in diabetes rats.Method：Diabetes rats were induced by STZ（52 mg.kg-1,peritioneal injection）.The rats were grouped for administrating with astragalus flavonoids,polysaccharides,and astragalosides accordingly for 4 weeks,then detection of blood glucose and ELISA assay of serum insulin and adiponectin were done.Result：The blood glucose of diabetes rats ascended（P 〈 0.05）,serum insulin and adiponectin descended（P 〈 0.05）,all of these changes were antagonised in various degrees by astragalus flavonoids,polysaccharides and astragalosides,spe-cially,the effect of astragalus flavonoids was obvious（P 〈 0.05）.Conclusion：The three active ingredients of Astrag-alus Radix could influence the content of blood glucose,serum insulin and adiponectin in diabetes rats,the best one was astragalus flavonoids.