华蟾素联合化疗治疗中晚期食管癌

A Clinical Study of Efficacy of Cinobufagin Injection Combined with ND Formula in Medium and Advanced Esophageal Patients

目的:比较观察华蟾素注射液联合化疗与单纯化疗对中晚期食管癌患者的疗效,以提高化疗效果,降低不良反应,改善患者的生活质量。方法:将70例食管癌患者随机分成对照组和治疗组2组,每组各35例,对照组采用化疗(ND)方案单纯化疗法,用含去甲长春花碱(NVB)联合顺氯氨铂(DDP)化疗;治疗组采用联合化疗法,化疗方案与对照组相同,并每天用20 mL华蟾素注射液加入500 mL 5%的葡萄糖注射液,采用静滴方式给药,1周期21 d计,每组患者进行2周期的治疗。2周期治疗后分别以近期疗效、不良反应及生存质量3项作为评价指标,来评价疗效。结果:治疗组和对照组的有效率分别为62.8%,48.5%,经统计分析有显著性差异(P<0.01);生存质量的改善程度也具有显著性差异(P<0.01);治疗组的不良反应发生率低于对照组。结论:华蟾素注射液联合化疗对中晚期食管癌患者化疗的疗效较好,同时降低了不良反应的发生率,改善了患者的生存质量,值得在临床上进一步推广应用。

Objective：The present study aimed at comparing and analysing the effect of single chemothera-py and the chemotherapy combined with Cinobufagin in the medium and advanced esophageal patients,in order to the strength chemotherapy’s effects,improve the patients’ life qualities,and reduce the side effects.Method：Seventy cases of esophageal patients were randomLy divided into two groups,35 patients for each group.The control group were treated by the single ND chemotherapy,using NVB combined with DDP;while the treatment group were treated by 20 mL Cinobufagin injection and 500 mL 5% glucose infusion iv,once a day,at the same time with chemothera-py,the chemotherapy method was the same as the control group.We took 21 days as one period.After two weeks’ treatment,we analyzed the effect,the patients’ life qualities and the side effects of the two groups.Result：The effec-tive rate of treatment group and control group were 62.8%,48.5%,they have the statistic significance（P 〈 0.05）.The patients’ life qualities between the two groups have statistic significance（P 〈 0.05）.The treatment group’s side effects incidence rate was lower than the control group.Conclusion：The Cinobufagin injection combined with chem-otherapy had a better effect in the esophageal patients,reduced the side effects and improved the patients’ life quali-ties,deserved to be used in the clinical furtherly.