咪喹莫特对尖锐湿疣患者血清干扰素-γ表达的影响

Induction of imiquimod on IFN-T in patients with condyloma acuminatum

目的研究咪喹莫特对尖锐湿疣患者外周血干扰素γ（IFN-γ）表达的诱导作用。方法利用荧光定量聚合酶链反应法测定22例尖锐湿疣患者治疗前后外周血及20例健康对照者外周血中IFN-γmRNA的定量表达。结果尖锐湿疣患者治疗前外周血中IFN-1mRN的表达水平低于健康对照者（t=-2．87，P=0．0071），咪喹莫特治疗8周后，皮损消退，外周血中IFN-γmRNA的表达水平高于治疗前的表达水平（t=-2．51，P=0．0159），但与健康对照者的表达水平差异无统计学意义（t=-1．07，P=0．2922）。结论咪喹莫特可诱导尖锐湿疣患者外周血IFN-γmRNA的表达，这可能是其治疗尖锐湿疣的作用机制之一。

Objective To study the induction of imiquimod on interferon-gamma （IFN-γ） in the peripheral blood of patients with condyloma acuminatum. Methods Twenty-two adult patients with condyloma acuminatum and twenty health control were sequentially enrolled in this study. Serum levels of IFN-γ mRNA were measured by realtime polymerase chain reaction in 22 cases with condyloma acuminatum before and after treatment with imiquimod for 8 weeks and 20 health control. Results The serum level of IFN-γ mRNA before treatment was significantly lower than that of health control （ t = - 2.87, P = 0. 0071 ）. Expression of serum IFN-γ mRNA in condyloma acuminatum was significantly increased after 8 weeks imiquimod treatment （t = -2.51, P = 0. 0159）. The serum level of IFN-γ mRNA had no significant difference compared with after treatment group and health control group （ t = - 1.07, P = 0. 2922）. Conclusion Imiquimod could increase the low expression of IFN-γmRNA in patients with condyloma acuminatum.