一清胶囊联合头孢克洛治疗单纯型过敏性紫癜

Analysis of Clinical Efficacy of Yiqing capsules and Cefaclor Tablets in Treatment of Simplex Anaphylactoid Purpura

目的评价一清胶囊联合头孢克洛治疗单纯型过敏性紫癜患者的临床疗效。方法随机、单盲、对照临床试验，入组191例单纯型过敏性紫癜患者，咽部分泌物A组乙型溶血链球菌抗原检测均为阳性。对照组92例口服头孢克洛片和常规治疗，治疗组99例在对照组基础上口服-清胶囊。结果治疗10d后，治疗组、对照组有效率分别为91．9％、75．0％，治疗组有效率明显高于对照组（P〈0．01）；咽拭子复检阴转率，治疗组、对照组阴转率分别为96．0％、87．0％，治疗组咽拭子复检阴转率明显高于对照组（P〈0．01）；治疗组起效时间明显早于对照组（P〈0．01）；3个月复发率，治疗组低于对照组（P〈0．05）。结论一清胶囊联合头孢克洛治疗单纯型过敏性紫癜，能提高疗效，缩短治疗时间。

Objective To investigate the efficacy of Yiqing capsules and Cefaclor tablets in the treatment of simplex anaphylaetoid purpura. Methods In this randomized ,simple-blind, controlled study, all of 191 simplex anaphylaetoid purpura patients ,the throat secretion Group A βhemolytic streptococci antigen test was positive ,92 patients of control group were treated Cefaclor tablets and regular treatment,99 patients of test group were Yiqing capsules and Cefaclor tablets. Results After 10 days treatment,the clinical efficacy of the test group and the control group were 91.9% ,75.0% ,the test group was obviously higher than that of the control group（ P 〈 0.01 ）, and the negative rate of the throat secretion Group A βhemolytic Streptococci antigen test of the test group was higher than that of control group, （ P 〈 0.01 ）. the commencements of response of the test group was earlier than that of the control group （ P 〈 0.01） ,the frequencies of recurrence of the test group were lower than that of the control group （P 〈 0. 05 ）. Conclusion Yiqing capsules combined cefaclor in treatment of simplex allergic purpura could improve efficacy, and reduce the treatment time.