鸦胆子油乳联合顺铂治疗恶性胸腔积液临床观察

Clinical observation of perfusion of bruceoUc oil emulsion and cisplatin for treatment malignant pleural effusion

目的观察鸦胆子油乳联合顺铂胸腔内注射治疗恶性胸腔积液的疗效及不良反应。方法64例恶性胸腔积液患者，按数字表法随机分为治疗组和对照组各32例，经胸腔穿刺中心静脉导管置管引流胸腔积液，再向胸腔内注入药物；治疗组用鸦胆子油乳60—80ml／次，每周1次；顺铂60mg／m^2，用0．9％氯化钠注射液60ml稀释，每周1次；对照组单用顺铂60mg／m^2，每周1次；连续治疗4周观察疗效。结果两组有效率比较：治疗组为81．3％，对照组56．3％，两组差异有统计学意义（X^2=4．65，P〈0．05）；不良反应：两组差异无统计学意义（P〉0．05）。结论鸦胆子油乳联合顺铂胸腔内注射治疗恶性胸腔积液疗效确切，不良反应小，值得临床推广。

Objective To evaluate the short-term efficacy and toxicity of perfusion in pleural cavity with bruceolic oil emulsion and eisplatin for malignant pleural effusion. Methods 64 patients with malignant pleural effusion received thoracentesis catheterization in pleural cavity and were devided into 2 groups：the treatment group and the control group. The treatment group （ 32 cases） were perfused with bruceolic oil emulsion 60 - 80ml every time and DDP 60mg/m2. The control group（32 cases） were perfused with DDP 60mg/m2 only,they used it once a week. All patients completed therapy 4 weeks. Results The response rate of treatment group was 81.3% and 56.3% for the control group （ X^2 = 4.65,P 〈 0. 05 ）. There was no difference in toxicity between two groups （ P 〉 0. 05 ）. Conclusion The efficacy of perfusion with bruceolic oil emulsion and cisplatin in pleural cavity was of promise. It could improve the life quality of the patients. The toxicity is weak, it was worth of clinical application.