罗美沙星在鸡体内的药物动力学与生物利用度研究

PHARMACOKINETICS AND BIOAVAILABLITY OF LOMEFLOXACIN IN HEALTHY BROILER CHICHENS

采用反向高效液相色谱法， 研究了罗美沙星在健康鸡体内的药动学与生物利用度。结果表明， 鸡静注罗美沙星后的ｃｉ－ ｔｉ数据符合二室开放模型， 其主要动力学参数如下： ｔｔ／２α０５６±０１２ｈ， ｔ１／β７６９±０７９ ｈ， Ｖｄ２１６±０３５ Ｌ／ｋｇ， Ｃ Ｌ Ｂ０２０±００３ Ｌ／ｋｇ·ｈ， Ａ Ｕ Ｃ ５２１９±８９９ ｕｇ／ｍ Ｌ·ｈ。鸡内服、肌注罗美沙星ｃ１－ ｔ１ 数据， 均符合有吸收因素二室模型， 内服的主要动力学参数如下： ｔ１／２ｋａ１１８±０１４ ｈ、ｔ１／２α２４５±０４６ ｈ、ｔ１／２β１７２１±１５８ ｈ、 Ａ Ｕ Ｃ ３８７８±６３３ ｕｇ／ｍ Ｌ·ｈ、ｔｍａｘ３１６＋ ０２３ ｈ、 Ｃｍ ａｘ２０６±０４３ ｕｇ／ｍ Ｌ、 Ｆ７４３１％ ； 肌注的主要动力学参数是： ｔ１／２ｋａ０６７±０１２ ｈ、ｔ１／２α１３０±０２３ ｈ、ｔ１／２β１１５２±１０２ｈ、 Ａ Ｕ Ｃ ４３１５±２０４ ｕｇ／ｍ Ｌ·ｈ、ｔｍ ａｘ１７６±０２０ ｈ、 Ｃｍａｘ４６０±ｕｇ／ｍ Ｌ、 Ｆ８２６８％ 。本文还就罗美沙星的临床应用进行了药动学评价。

The pharmacokinetics and bioavailability of lomefloxacin in healthy broilers were studied following single intravenous, oral and intramuscular administration at 10 mg/kg dosing rate by using a reversed phase high performance chromatagraphy (HPIC) procedure. The results obtained showed that the plasma c i-t i data of lomefloxacin after intravenous administration in healthy broilers were best described by a twocompartment open model. The main pharmacokinetic parameters were as follows:t 1/2α 0 56±0 12 h,t 1/β 7 69±0 79 h,Vd 2 16±0 35 L/kg,CL B 0 20±0 03 L/kg.h、AUC 52 19±8 99 ug·mL.h. The c i-t i data of lomefloxacin in plasma following both oral and intramuscular administration in healthy broilers were fitted to a two two-compartment open model with first-order absorption. The main parameters after oral administratiion were as follows:t 1/2ka 1 18±0 14 h、t 1/2α 2 45±0 46 h、t 1/2β 17 21±1 58 h、AUC 38 78±6 33 ug·mL.h、t max 3 16±0 23 h、 C max 2 06±0 43 ug/ml、 F74 31%;The main parameters after intramuscular administration were as follows:t 1/2ka 0 67±0 12 h、t 1/2α 1 30±0 23 h、t 1/2β 11 52±1 02 h、AUC 43 15±2 04 ug·mL.h、t max 1 76±0 20 h、C max 4 60±0 61 ug·mL、F 82 68%、The pharmacokinetic evaluation was alos conducted on the clinical applications of lomefloxacin in this report. $$$$