神经元簇状放电锋电位数的研究

THE NUMBER OF SPIKES PER BURST

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摘要利用水蛭心脏细胞的神经元膜电位的动力学方程,讨论外界刺激电流对簇状放电中锋电位数目的影响,发现外界刺激电流和非失活钾离子通道激活电位具有相同的作用,神经元的活动状态随着外界刺激电流的变化,可以在簇状放电、持续放电和无放电三种状态之间转换.神经元簇状放电时,刺激电流导致神经元膜电位的去极化程度越高,在一次簇状放电过程中产生的锋电位数也越多. Bursting is a typical neuronal firing pattern.The number of spikes per burst plays an important role in implementation of neural function and computation.In this paper,stimulation-induced changes in the number of spikes per burst were studied using a reduced dynamic model for leech heart interneurons.Data indicated that external stimulation had similar effect on neural activity in regards to noninactivating potassium potential： neuronal firing pattern switched between bursting,tonic spiking and steady state.When neuronal firing is in bursts,with greater membrane-depolarization,greater number of spikes were found in a burst.

作者孟艳张丹王大辉

机构地区北京师范大学管理学院

出处《北京师范大学学报（自然科学版）》 CAS CSCD 北大核心 2011年第1期104-107,共4页 Journal of Beijing Normal University(Natural Science)

基金国家自然科学基金资助项目(60974075) 留学回国人员科研启动基金资助项目

关键词神经元模型簇状放电锋电位 bursting neuron model spike

分类号 TP18 [自动化与计算机技术—控制理论与控制工程]

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北京师范大学学报（自然科学版）

2011年第1期

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神经元簇状放电锋电位数的研究

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