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Th17/CD4^+ CD25^+ Treg细胞失衡与儿童急性再生障碍性贫血免疫发病机制的关系 被引量：2

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摘要 我国是儿童急性再生障碍性贫血（aplastic anemia,AA）的高发国家。然而急性AA的发病机制尚不明确,治疗措施针对性不强,导致其治疗效果不佳,病死率极高。Th17细胞及其分泌的细胞因子介导炎症反应,能诱导严重自身免疫性疾病;
作者 王会平 王宁玲 翟志敏
机构地区 安徽医科大学第二附属医院血液科 安徽医科大学第二附属医院中心实验室
出处 《中国小儿血液与肿瘤杂志》 CAS 2011年第1期38-41,共4页 Journal of China Pediatric Blood and Cancer
关键词 急性再生障碍性贫血 免疫发病机制 CD25^+ 细胞失衡 儿童 自身免疫性疾病 介导炎症反应 Th17细胞
分类号 R725.5 [医药卫生—儿科]
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参考文献21

  • 1Solomou EE, Rezvani K, Mielke S, et al. Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastie anemia. Blood, 2007,110 : 1603-1606.
  • 2Yan Gu, Xiaojing Hu, Chuanfang Liu, et al. Interleukin (IL)-17 promotes macrophages to produce IL-8, IL-6 and tumour necrosis factor-a in aplastic anaemia. Br J Haematol, 2008, 142 : 109-114.
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同被引文献21

  • 1黄绍良,黄永兰.儿童特发性再生障碍性贫血的诊断与治疗[J].中国当代儿科杂志,2009,11(2):81-87. 被引量：4
  • 2Young NS, Bacigalupo A, Marsh JC. Aplastic anemia:Pathophysiology and treatment[ J]. Biol Blood Marrow Transplant,2010,16 (1 suppl) : 119 - 125.
  • 3Chang MH, Kim KH, Kim HS,et al. Predictors of response to immuno- suppressive therapy with antithymocyte globulin and cyclosporine and prognostic factors for survival in patients with severe aplastic anemia [J]. Eur J Haematol,2010,84(2) :154 - 159.
  • 4Scheinberg P, Colin OW, Nunez O,et al. Treatment of severe aplastic a- nemia with a combination of horse antithymocyte globulin and eyelospo- fine, with or without sirolimus: A prospective randomized study [ J ]. Haematologica,2009, 94 ( 3 ) : 348 - 354.
  • 5Sakaguchi S,Miyara M,Costantino CM,et al.FOXP3+ regulatory T cells in the human immune system[J].Nat Rev Immunol,2010,10:490-500.
  • 6Afzali B,Lombardi G,Lechler RI,et al.The role ofT helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease[J].Clin Exp Immunol,2007,48:32-46.
  • 7de Latour RP,Visconte V,Takaku T,et al.Th17 immune responses contribute to the pathophysiology of aplastic anemia[J].Blood,2010,116:4175-4184.
  • 8Shi J,Ge M,Lu S,et al.Intrinsic impairment of CD4(+)CD25 (+) regulatory T cells in acquired aplastic anemia[J].Blood,2012,120:1624-1632.
  • 9Young NS.Current concepts in the pathophysiology and treatment of aplastic anemia[J].Hematology Am Soc Hematol Educ Program,2013:76-81.
  • 10Passweg JR,Aljurf M.Treatment and hematopoietic SCT in aplastic anemia[J].Bone Marrow Transplant,2013,48:161.

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中国小儿血液与肿瘤杂志
2011年 第1期

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