摘要
目的：探讨碱性成纤维细胞生长因子（bFGF）对视网膜挫伤的保护作用及其机制.方法：54只SD大鼠随机分为正常组、挫伤组及挫伤治疗组，对自由落体致视网膜挫伤的SD大鼠在伤后即刻玻璃体腔内注射bFGF，并于损伤后3小时、12小时、24小时、72小时及120小时分别测定挫伤组及挫伤治疗组视网膜SOD、MDA及Ca2＋含量的变化，并与正常组进行比较。结果：与正常组相比，挫伤组大鼠视网膜MDA、Ca2＋含量明显上升，SOD含量明显下降（P〈0．05）、而与挫伤组相比，挫伤治疗组视网膜MDA、Ca2＋含量均较降低，SOD含量则明显升高.结论：早期应用bFGF可以抑制视网膜内自由基的产生及Ca2＋的超载，对视网膜挫伤具有保护作用。
To investigate the neurnprotective effect of basic fibrobtast growth factor （bFGF） on retina blunt trauma. Methods： Fifty-four Sprague-Dawley rats were randomly assigned to one of three groups： control, trauma and treatment. In treatment group, bFGF was administered intravitreously immediately following retina blunt trauma. The cnnlents of SOD,MDA and Ca2＋ in retina were measured at 3h ,12h, 24h, 72h and 120h after retina blunt trauma. Results ： Compared with control group, the contents of MDA and Ca2＋ in retina increased markedly（P 〈 0.05） while the contenls of SOD decreased significantly （P 〈 0.05）. However, the coulents of MDA and Ca2＋in treatment group were significantly lower than those in trauma group （P 〈 0.05）.while decreased of SOD was inhibited. Conclusion：bFGF used in early stage can inhibited the increase of free radicals and the calcium overload in retina and attenuate retina blunt trauma.
