硝苯地平联合特拉唑嗪治疗老年原发性高血压的临床疗效观察

Nifedipine United Terazosin elderly patients with essential hypertension clinical observation

目的：观察与探讨硝苯地平联合特拉唑嗪治疗老年原发性高血压的临床效果。方法：将我院2009年1月-2010年6月收治的42例老年原发性高血压患者，将其随机平均分为2组，即对照组和治疗组，对照组21例采用硝苯地平进行治疗，治疗组采用硝苯地平联合特拉唑嗪进行治疗；观察和记录2组患者治疗前后的血压水平以及评定合并良性前列腺增生患者治疗前后国际前列腺’症状（Internationalprostatesymptomscores，IPSS）评分及生活质量（thequalityoflife，QOL）评分，并对治疗后的不良反应进行观测和记录。结果：治疗组显效16例、有效3例、无效2例，总有效率90．5％；对照组显效9例、有效6例、无效6例，总有效率71．4％；治疗组的血压水平显著高于对照组（P〈0．05）；合并良性前列腺增生老年男性原发性高血压患者治疗后IPSS评分和QOL评分明显低于治疗前，前后结果差异有统计学意义（P〈0．05）；对照组与治疗组对患者的血糖与肝肾功能未发现不利影响，并且治疗组对血脂的改善有着一l定的积极作用。结论：硝苯地平联合特拉唑嗪治疗老年原发性高血压具有非常明显的临床疗效，并且安全可靠、起效平稳、具有一定改善血脂的作用．其临床疗效明显优于单纯的硝苯地平加量治疗。

Objective： To observe and investigate the joint Nifedipine Terazosin the clinical effects of essential hypertension. Methods： The hospital in January 2009 -2010 on June 42 elderly patients treated hypertensive patients were randomly divided into 2 groups, control group and Irealmenl group and the control group, 21 eases were treated with nifedipine were treated with nifedipine combined treatment group were treated with lerazosin; observed and recorded two groups of patients before and after treatment and lhe assessment of blood pressure levels in patients with combined treatment of benign prostatic hyperplasia before and after the International Prostate Symptom （Internalional prostale symptom scores, IPSS） score and quality of life （the quality of life, QOL） score, and adverse reactions afler treatment were observed and rectodeal. Results： The Ireatment group 16 cases, effective in 3 cases, 2 cases, total effective rate 90.5%; control group, 9 cases were markedly effeclive in 6 cases. 6 cases, total effeclive rate 71.4%; Ireatment group was significantly higher than blood pressure the control group （P 〈0.05）; combination of benign prostalic hyperplasia treatmenl of elderly male patients with essential hypertension after the IPSS score and QOL score was significantly lower than before Irealment, there was significant difference between the results before and after （P 〈0.05）; control group and treahnent group of palients with blood glucose and liver and kidney function did not find adverse effects on blood lipids and improve the Ireatment group had a positive role. Conclusion： Nifedipine Terazosin United essential hypertension is of obvious clinical efficacy, and safe, reliable, steady onset, with some improvement in the role of lipids and ils clinical efficacy was significantly better thint nifedipine increase the amount of treatment.