如意金黄巴布剂中小檗碱经皮渗透研究

Studies on Percutaneous Absorption of Berberine from Ruyijinhuang Adhesive Tape

采用改良Ｆｒａｎｚ扩散池法和人体剩余量法，研究如意金黄巴布剂中小檗碱的经皮渗透特性，ＨＰＬＣ法检测透过的小檗碱。结果表明：小檗碱可以透过皮肤而被吸收，其经皮渗透过程符合Ｈｉｇｕｃｈｉ方程，而且两种透皮试验方法具有良好的相关性。提示如意金黄巴布剂经皮渗透效果良好，适于经皮给药。体外透皮试验在一定程度上可以反映药物透皮吸收的真实情况。

Percutaneous absorption of berberine from Ruyijinhuang adhesive tape was studied by improved Franz diffusing cells and residual dosage methods. The permeated berberine was determined by HPLC. The results showed that berberine in Ruyijinhuang adhesive tape could penetrate through skin and be absorbed. The process of Penetration could be described by Higuchi equation. The two percutaneous test methods showed a significant correlationship suggesting that Ruyijinhuang adhesive tape is suitable for administration through skin.