期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Tau蛋白——新型阿尔茨海默病治疗药物研发靶点 被引量：1

原文传递
导出
摘要 阿尔茨海默病（Alzheimer disease，AD）是老年痴呆症中最主要的类型，其主要临床特征是记忆力丧失以及推理、判断、语言能力的受损。AD将成为21世纪威胁人类的最严重疾病之一，据统计仅美国就有450万例AD患者，65岁以上人群发病率为10％，治疗和护理费用昂贵，带来了严重的社会经济负担。AD的发病机制尚未完全阐明，主要病理改变为神经细胞外以β淀粉样蛋白（Aβ）为中心的蛋白斑和脑细胞内过度磷酸化的微管相关蛋白（Tau蛋白）构成的神经纤维缠结（NFT）。
作者 孙钦松
机构地区 胜利石油管理局胜利医院药剂科
出处 《中国医师进修杂志》 2011年第3期73-74,共2页 Chinese Journal of Postgraduates of Medicine
关键词 阿尔茨海默病 TAU蛋白 药物研发 治疗 神经纤维缠结 靶点 AD患者 社会经济负担
分类号 R749.16 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献11

  • 1Bolognesi ML,Matera R,Minarini A,et al.Alzheimer's disease:new approaches to drug discovery.Curr Opin Chem Biol,2009,13 (3):303-308.
  • 2Brunden KR,Ballatore C,Crowe A,et al.Tau-directed drug discovery for Alzheimer's disease and related tauopathies:a focus on tau assembly inhibitors.Exp Neurol,2010,223(2):304-310.
  • 3Williams M.Progress in Alzheimer's disease drug discovery:an update.Curr Opin Investig Drugs,2009,10(1):23-34.
  • 4Rafli MS,Aisen PS.Recent developments in Alzheimer's disease therapeutics.BMC Med,2009(7):7.
  • 5张明明,何美霞,华海婴.tau蛋白和退行性神经病变[J].中国老年学杂志,2009,29(2):251-253. 被引量：5
  • 6Clavaguera F,Bolmont T,Crowther RA,et al.Transmission and spreading of tauopathy in transgenic mouse brain.Nat Cell Biol,2009,11(7):909-913.
  • 7Brunden KR,Trojanowski JQ,Lee VM.Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies.Nat Rev Drug Discov,2009,8(10):783-793.
  • 8Sabbagh MN.Drug development for Alzheimer's disease:where are we now and where are we headed? Am J Geriatr Pharmacother,2009,7(3):167-185.
  • 9Mangialasche F,Solomon A,Winblad B,et al.Alzheimer's disease:clinical trials and drug development.Lancet Neurol,2010,9 (7):702-716.
  • 10Azorsa DO,Robeson RH,Frost D,et al.High-content siRNA screening of the kinome identifies kinascs involved in Alzheimer's disease-related tau hyperphosphorylation.BMC Genonies,2010(11):25.

二级参考文献19

  • 1Sergeant N, Bretteville A, Hamdane M, et al. Biochemistry of tau in Alzheimer's disease and related neurological disorders [ J ]. Expert Rev Proteomics,2008 ; 5 (2) :207 -24.
  • 2Boeve BF, Hutton M. Refining frontotemporal dementia with parkinsonism linked to chromosome 17 :introducing FTDP-17 (MAPT) and FTDP-17 ( PGRN ) [ J ]. Arch Neurol,2008 ;65 (4) :460-4.
  • 3Jellinger KA. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia [ J ]. Neurodegener Dis, 2008 ; 5 ( 3- 4) :118-21.
  • 4Ballatore C, Lee VM, Trojanowski JQ. tau-mediated neurodegeneration in Alzheimer's disease and related disorders[ J ]. Nat Rev Neurosci ,2007;8 (9) :663-72.
  • 5Perez M, Santa-Maria I ,Tortosa E, et al. The role of the VQIVYK peptide in tau protein phosphorylation [ J ]. J Neurochem, 2007 ; 103 ( 4 ) : 1447- 60.
  • 6Liu Y, Liu F, Iqbal K, et al. Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease [ J ]. FEBS Lett,2008 ;582(2) :359-64.
  • 7Deng Y, Li B, Liu F,et al. Regulation between O-GlcNA cylation and phospborylation of neurofilament-M and their dysregulation in Alzheimer disease[ J]. FASEB J,2008 ;22 ( 1 ) :138-45.
  • 8Terwel D, Lasrado R, Snauwaert J,et al. Changed conformation of mutant tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of tau-4R/2N transgenic mice[J]. J Biol Chem,2005 ;280(5 ) :3963-73.
  • 9Maeda S, Sahara N, Saito Y, et al. Granular tau oligomers as intermediates of tau filaments [ J ]. Biochemistry,2007 ;46 ( 12 ) :3856-61.
  • 10de la Torte JC. Pathophysiology of neuronal enemy crisis in Alzheimer's disease[J]. Neurodegener Dis,2008 ;5 ( 34 ) : 126-32.

共引文献4

同被引文献13

  • 1中国防治认知功能障碍专家共识专家组.中国防治认知功能障碍专家共识[J].中华内科杂志,2006,45(2):171-173. 被引量：553
  • 2Senathi-Raja D,Ponsford J,Sch? n berger M.Impact of age on lon-term cognitive function after traumatic brain injury.Neuropsychology,2010,24(3):336-344.
  • 3Hattori N,Swan M,Stobbe GA,et al.Differential SPECT activation patterns associated with PASAT performance may indicate frontocerebellar functional dissociation in chronic mild traumatic brain injury.J Nucl Med,2009,50(7):1054-1061.
  • 4Govind V,Gold S,Kaliannan K,et al.Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits.J Neurotrauma,2010,27(3):483-496.
  • 5Ardila A,Moreno S.Neuropsychological test performance in Aruaco Indians:an exploratory study.J Int Neuropsychol Soc,2001,7(4):510-515.
  • 6DeKosky ST,Abrahamson EE,Ciallella JR,et al.Association of increased cortical soluble A1-42 levels with diffuse plaques after TBI in humans.Arch Neurol,2007,64(4):541-544.
  • 7Loane DJ,Pocivavsek A,Moussa CE,et al.Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.Nat Med,2009,15(4):377-379.
  • 8Thomsen MS,Hansen HH,Timmerman DB,.et al.Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors:from animal models to human pathophysiology.Curr Pharm Des,2010,16(3):323-343.
  • 9胡锦,姚海军,刘永,奚才华,谢叻,吴巧娇,付朝伟,滕良珠,汪业汉,傅先明,惠国桢,傅震,杨卫忠,石松生,吕世亭,刘伟国,徐庚生,洪涛,周良辅.华东地区颅脑创伤流行病学调查[J].中华神经外科杂志,2008,24(2):88-91. 被引量：60
  • 10杨定东,戴泽平.全身麻醉药与术后认知功能障碍及阿尔茨海默病[J].国际麻醉学与复苏杂志,2008,29(4):345-348. 被引量：6

引证文献1

二级引证文献18

中国医师进修杂志
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部