晚期胰腺癌的持续腹腔动脉插管化疗

Continuous Coeliac Arterial Infusion Polychemotherapy for Advanced Pancreatic Cancer

为了观察和评价晚期胰腺癌持续腹腔动脉插管化疗效果，对７例晚期胰腺癌患者行腹腔动脉插管并留置，６例采用ＴＨＰＡＤＭ＋ＨＣＰＴ＋ＣＦ／５Ｆｕ方案，另１例采用Ｇｅｍｃｉｔａｂｉｎｅ＋ＣＦ／５Ｆｕ方案，持续滴注４ｄ。结果完全缓解１例，部分缓解３例，无变化２例，进展１例，有效率为５７．１％（４／７），临床受益疗效７１．４％（５／７）。２例已死亡，５例生存，中位生存期５个月。结果表明持续腹腔动脉插管化疗对晚期胰腺癌有较好疗效，值得临床进一步观察研究。

To observe and evaluate the efficiency of continuous coeliac arterial infusion polychemotherapy on advanced pancreatic cancer.4 day long continuous coeliac arterial infusion polychemotherapy was performed in 7 patients with advanced pancreatic cancer,the regimen of pirarubicin,hydroxycamptothecine,calcium folinate and fluorouracil was used in 6 cases and gemcitabine,calcium folinate and fluorouracil in 1.Short term efficiency:complete remission (CR) occured in 1 cases,partial remission(PR) in3,no change(NC) in 2 and progression disease(PD) in 1.The overall response rate (RR) was 57% (4/7).Clinical benefit response(CBR) was 71%(5/7).The median survival time was 5 months.5 patients survived and 2 patients died.Continuous coeliac arterial infusion polychemotherapy is more effective to advanced pancreatic cancer and worth further study.