摘要
系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种复杂的多基因自身免疫性疾病,遗传因素重要而复杂。SLE的易感基因包括人类白细胞抗原(HLA)基因、免疫球蛋白Fc受体(FcR)基因、细胞毒性T细胞相关抗原4(CTLA-4)基因、免疫球蛋白受体同源体(FcRL)基因等。对易感基因单核苷酸多态性(single nucleotide polymorphism,SNP)的研究有助于阐明SLE的易感性和临床表型。
Systemic lupus erythematosus is a complex polygenic autoimmune disease.The genetic factor is important and complex.The predisposing gene of systemic lupus erythematosus include human leukocyte antigen gene,Fc receptor gene,cytotoxic T lymphocyte-associated antigen-4 gene and Fc receptor homolog gene etc.The research on predisposing gene SNPs contribute to illustrate the susceptibility and clinical phenotype.
出处
《中国优生与遗传杂志》
2011年第2期12-14,共3页
Chinese Journal of Birth Health & Heredity
关键词
系统性红斑狼疮
基因
单核苷酸多态性
Systemic lupus erythematosus
Gene
Single nucleotide polymorphism
