AQP1和HGF在胎儿窘迫患者胎盘中的表达及意义

Study the expression and significance of AQP1 and HGF in placental fetal distress

目的探讨急性胎儿窘迫患者胎盘中AQP1及HGF的变化水平及其意义。方法采用免疫组化方法检测急性胎儿窘迫组及正常产妇胎盘中AQP1、HGF的蛋白水平。结果 (1)急性胎儿窘迫组AQP1表达比对照组明显升高,差异有统计学意义(t=16.94,P<0.001)。与对照组比较,急性胎儿窘迫组HGF降低,差异有统计学意义(t=33.51,P<0.001)。(2)胎盘组织中AQP1与HGF蛋白表达水平呈负相关关系(r=-0.375,P<0.01)。结论胎盘中AQP1升高及HGF降低,可引起胎盘缺血缺氧,从而参与胎儿窘迫的病理生理过程。

Objective：To investigate the of Aquaporin 1（AQP1） and HGF in fetal distress placenta.Methods：Immunohistochemistry used to investigate the expression of AQP1 and HGF protein in placental from fetal distress and normal group.Results：（1） Expression of AQP1 protein level in placenta of fetal distress higher than that normal group（P0.001）.Expression of HGF in placenta of fetal distress was significantly lower than that normal group（P0.001）.（2）There was significant inverse correlation between the level of AQP1 and HGF in placenta of normal group and fetal distress group.Conclusion：It suggested that abnormal protein expression of AQP1 and HGF may play important roles in the path-physiological processes of fetal distress.