孕妇血清总胆汁酸及其肝功能检测结果的分析

Analysis of TBA and liver function test during pregnacy

目的探讨孕妇血清总胆汁酸(TBA)、总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)的检测结果及其在临床上的应用价值。方法对1000例孕妇及100例正常对照妇女均采用循环酶分析法、钒酸盐氧化法、速率法进行TBA、TBIL、DBIL、ALT、AST的测定。结果孕妇组TBA、ALT、AST检测结果明显高于对照组,且差异有统计学意义(P<0.01),TBIL及DBIL检测结果略高于对照组,差异无统计学意义(P>0.05)。孕妇组TBA异常率为7.3%;TBIL异常率为0.6%;DBIL异常率为0.4%;ALT异常率为1.5%;AST异常率为1.8%。结论孕妇进行TBA、TBIL、DBIL、ALT、AST的测定能较好地反映妊娠期孕妇肝细胞损害及胆汁淤积的程度。对于孕妇妊娠过程中TBA持续升高应定期进行TBA的动态观察并结合其它诊断标准,以防妊娠肝内胆汁瘀积症(ICP)的发生。

Objective：To investigate the clinical application value of the test of TBA,TBIL,DBIL,ALT and AST during pragnancy.Methods：1000 cases of pregnant women and 100 cases of normal women as control were tested for TBA,TBIL,DBIL,ALT and AST by utilizing cyclophorase analysis,vanadate oxidation method and velocimetry.Results：The values of TBA,ALT and AST during pregnancy were significantly higher,and there is statistical significance（P0.01）.The values of TBIL and DBIL during pregnancy were slightly higher,and there is no statistical significance（P0.05）.The abnormal rate of TBA was 7.3%,and 0.6% for TBIL,0.4% for DBIL,1.5% for ALT,1.8% for AST.Conclusion：It is necessary to execute testing of TBA,ALT and AST during pragnancy.The testing of TBA is important for diagnosing of intrahepatic cholestasis of pregnancy（ICP）.