摘要
目的通过监测正常早孕、自然流产与异位妊娠妇女血清绒毛膜促性腺激素(β-HCG)及孕酮(P)水平,建立正常早孕、自然流产与异位妊娠的妊娠结局预测模式,并利用ROC曲线评价其预测妊娠结局的能力。方法选择正常早期单胎妊娠对照组191例,自然流产患者150例、异位妊娠患者204例。用电发光免疫法测血清β-HCG及P水平,建立单独β-HCG、P以及β-HCG和P联合积分预测模式。结果正常早孕组孕龄血清β-HCG平均值为(7812.52±3599.29)IU/L,P平均值为(35.27±12.91)nmol/L;自然流产组血清β-HCG平均值为(1298.07±1808.83)IU/L,P平均值为(6.66±4.42)nmol/L;异位妊娠组β-HCG平均值为(2118.23±2905.75)IU/L,P平均值为(6.37±5.58)nmol/L;自然流产组血清β-HCG及P水平明显低于正常早孕对照组,独立样本t检验t=21.75,P=0.000(95%CI:5925.31-7103.79)及t=28.49,P=0.000(95%CI:26.52-30.46),差异有显著性意义;异位妊娠组血清β-HCG及P水平明显低于正常早孕对照组,独立样本t检验t=17.25,P=0.000(95%CI:5045.02-6﹤343.57)及t=28.32,P=0.000(95%CI:26.79-30.79),差异有显著性意义;自然流产组与异位妊娠组血清β-HCG差异有显著性意义,t=-3.27,P=0.001(P<0.05),两组P水平差异无统计学意义,t=0.57,P=0.57(P>0.05);通过ROC曲线分析血清β-HCG、P水平及联合积分预测妊娠结局的能力,曲线下面积分别为0.879、0.973、0.984,(P值均<0.05),95%CI分别为(0.845-0.913)、(0.959-0.986)、(0.973-0.994)。结论单独P较β-HCG水平具有更好的预测非正常妊娠的能力;联合积分预测妊娠结局的能力最强;单独P和联合积分与单独β-HCG预测妊娠结局的能力的差异有统计学意义,但二者的差异无统计学意义;随妊娠时间的延长,正常早孕β-HCG水平有迅速增加的趋势,异位妊娠有缓慢增加的趋势,而自然流产则有降低趋势;P水平不能有效区分自然流产与异位妊娠。
Objective:The current study was undertaken to find out the predictive value of human chorionic gonadotropin and Progesterone between normal intrauterine pregnancies,spontaneous abortion and ectopic pregnancy.Methods:The study evaluated 545 naturally conceived and asymptomatic first trimester(204 ectopic pregnancy,150 failing and 191 normal intrauterine) with maternal serum beta HCG and P.Results:β-HCG and P level was significantly higher in normal intrauterine than that in spontaneous abortion and ectopic pregnancy,t=21.75,P=0.000(95%CI:5925.31-7103.79) and t=28.49,P=0.000(95%CI:26.52-30.46).The level of P was negatively in spontaneous abortion and ectopic pregnancy,P0.05.Conclusion:The elevated level of β-HCG and P is associated with the failing intrauterine.The ability of P to distinguish the failing intrauterine from the normal intrauterine is higher than that of β-HCG.The difference between spontaneous abortion and ectopic pregnancy can′t be predicted by β-HCG and P.The predictive power of P combined with β-HCG measurements in the outcome of threatened miscarriage is highest.
出处
《中国优生与遗传杂志》
2011年第2期73-75,49,共4页
Chinese Journal of Birth Health & Heredity