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宫颈癌组织中SHP-2与IL-6表达意义的研究 被引量:1

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摘要 SHP-2是蛋白酪氨酸磷酸酶家族中的一员,它是一个进化上相对保守的蛋白酪氨酸磷酸酶,其NH2-末端前后含有两个SH2结构域,COOH-末端含有1个具有催化活性的PTP结构域及富含脯氨酸基团和酪氨酸磷酸化位点的尾巴。超过90%宫颈癌患者是HPV感染的结果,
作者 孟斐
出处 《中国妇幼保健》 CAS 北大核心 2011年第4期594-595,共2页 Maternal and Child Health Care of China
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  • 1Huazhang An,Wei Zhao, Jin Hou, et al.SHP-2 phosphatase negatively regulates the TRIF adaptor protein-depent type linterferon and proinflammatory cytokine production.Immunity, 2006,25(6):919-928.
  • 2Du Z, Shen Y, Yang W.Inhibition of IFN-alpha signaling by a PKC- and protein tyrosinephosphatase SHP-2-dependent pathway.Proc Natl Acad Sei USA,2005,102 (29): 102-105.
  • 3宋利.SHP-2和转化生长因子β在中老年患者宫颈鳞癌组织中的表达[J].中国老年学杂志,2013,33(6):1247-1249. 被引量:2

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