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紫杉醇联合奈达铂治疗晚期非小细胞肺癌的临床观察 被引量:6

Effect of nedaplat and paclitaxel in treatment of advanced non-small cell lung cancer
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摘要 目的观察紫杉醇(PTX)联合奈达铂(NDP)治疗晚期非小细胞肺癌的疗效及不良反应。方法 48例晚期非小细胞肺癌患者应用紫杉醇(PTX)联合奈达铂(NDP)方案化疗:PTX 135~175 mg/m2,静脉滴注,第1天;NDP 80~100 mg/m2,静脉滴注,第2天,21 d为1个周期。结果全组48例患者中,完全缓解率(CR)3例(6.3%),部分缓解率(PR)16例(33.3%),稳定(SD)22例(45.8%),病情进展(PD)7例(14.6%)。有效率(RR)为39.6%,疾病控制率(DCR)为85.4%。主要不良反应为骨髓抑制及胃肠道反应,肝、肾毒性较轻。结论紫杉醇联合奈达铂治疗晚期非小细胞肺癌不良反应轻,疗效较好,值得临床推广。 Objective To evaluate the efficacy and side effects of combined chemotherapy with nedaplat plus paclitaxel in treatment of advanced non-small cell lung cancer. Methods Forty-eight patients with advanced non-samll cell lung cancer were treated with nedaplat plus paclitaxel.Paclitaxel was administered on days 1 at a dose of 135-175 mg/m2,nedaplat was administered on days 2 at a dose of 80-100 mg/m2,every 21 days was one cycle.Results Among the forty-eight patients,the response rates were 39.6%,disease control rate was 85.4%.Complete reponse rate was 6.3%,partial reponse rate was 33.3%,stable disease rate was 45.8%,progressive disease rate was 14.6%.The main side effects were neutropenia,thrombocytopenia,nausea and vomiting.There was no obvious side effect in liver or kidney.Conclusion Nedaplat combined paclitaxel were effective and has less side effect in the treatment of advanced non-small cell lung cancer,it deserves spreading and applying.
出处 《临床医学》 CAS 2011年第1期3-4,共2页 Clinical Medicine
关键词 紫杉醇 奈达铂 晚期非小细胞肺癌 Paclitaxel Nedaplat Advanced non-small cell lung cancer
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参考文献6

  • 1Inuyama Y,Miyake H,Horiuchi M,et al.A late phase Ⅱ clinical study of cisdiammine glycolato platinum,254-S,for head and neck cancers[J].Gan To Kagaku Pyoho,1992,19(6):871-877.
  • 2Fukuda M,Shinkai T,Eguchi K,et al.Phase Ⅱ study of (glycolate-0,0)diammineplatinum(Ⅱ),a novel platinum complex,in the treatment of non-small cell lung cancer[J].Cancer Chemother Pharmacol,1990,26(6):393-396.
  • 3徐瑞华,管忠震,姜文奇,黄河,胡晓桦,谢伟敏,李星庚,刘亚利,潘良熹,戴爱娣,庄武,张春,马智勇,王建华.奈达铂治疗非小细胞肺癌的Ⅱ期临床研究报告[J].癌症,2002,21(12):1354-1358. 被引量:132
  • 4谢伟敏,胡晓桦,宋向群,廖萍,刘志辉,周文献,李志革,于起涛.奈达铂治疗恶性肿瘤的Ⅱ期临床观察[J].广西医科大学学报,2003,20(5):691-694. 被引量:2
  • 5Noda K,Kato Y,Oshita F,et al.Phase Ⅰ/Ⅱ study of an escalating dose of nedaplatin in combination with irinotecan for advanced nonsmall cell lung cancer[J].Cancer Chemother Pharmacol,2003,52(1):73-78.
  • 6马锐,伞宝君.紫杉醇联合顺铂治疗晚期非小细胞肺癌的临床研究[J].临床肿瘤学杂志,2005,10(2):128-129. 被引量:14

二级参考文献20

  • 1[1]Ota K.Nedaplatin.Gan To Kagaku Ryoho.1996,23(3):379-387.
  • 2[3]Lebwohl D,Canetta R.Clinical development of platinum complexes in cancer therapy:an historical per-spective and an update.Eur J Cancer,1998,34(10):1522-1534.
  • 3[4]Takigawa N,Segawa Y,Ueoka H,et al.Combination of nedaplatin and vindesine for treatment of relapsed or refractory non-small cell lung cancer.Cancer Chemother Pharmacol,2000,46(4):272-278.
  • 4[5]Schiller JH,Harrington D,Belani CP,et al.Comparison of four chemotherapy regimens for advanced non-small cell lung cancer.N Eng J Med,2002,346(2):92-98.
  • 5[6]Fujii M,Tokumaru Y,Imanishi Y,et al.Combination chemotherapy with nedaplatin and 5-Fu for headneck cancer.Jpn J Cancer Chemother,1998,25(1):53-58.
  • 6[7]Yoshioka T,Gamoh M,Shineha R,et al.A new combim-ation chemotherapy with cis-diammine-glycolato-platinu-m(nedaplatin)and 5-fluorouracil for advance desoiphage-al cancers.Intern Med,1999,38(11):844-848.
  • 7[8]Matsumoto M,Takeda Y,Maki H,et al.Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer.Jpn J Cancer Res,2001,92(1):51-58.
  • 8Taguchi T, Wakui A, Nabeya K, et al. A phase II clinical study of cis-diammine glycolato platinum, 254-S, for gastrointestinal cancers. 254-S Gastrointestinal Cancer Study Group [J]. Gan To Kagaku Ryoho, 1992,19(4):483-488.
  • 9Inuyama Y, Miyake H, Horiuchi M, et al. A late phase II clinical study of cis-diammine glycolato platinum, 254-S, for head and neck cancers [J]. Gan To Kagaku Ryoho, 1992,19(6): 871-877.
  • 10Le Chevalier T, Brisgand D, Douillard JY, et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: results of a European multicenter trial including 612 patients[J]. J Clin Oncol, 1994,12:360-367.

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