枸橼酸莫沙比利对小鼠胃肠运动的影响

The effect of Citrate Mosapride on gastrointestinal motility in mice

目的:观察枸橼酸莫沙比利对小鼠胃肠运动的影响。方法:60只正常小鼠随机分为枸橼酸莫沙比利组、多潘立酮组及正常对照组,分别检测各组小鼠胃内色素相对残留率及小肠推进比,并进行组间比较。结果:枸橼酸莫沙比利组小鼠胃内色素相对残留率较正常对照组低(P<0.05),与多潘立酮组相比无显著性差异(P>0.05),小肠推进比较正常对照组高(P<0.05),优于多潘立酮组(P<0.05)。结论:枸橼酸莫沙比利对正常小鼠的胃排空及肠推进运动均有明显的促进作用,为全胃肠道的促动力药物。

Objective：To investigate the effect of Citrate Mosapride on gastrointestinal motility in mice.Methods：60 normal mice were randomly divided into three groups：Citrate Mosapride group,domperidone group and contrast group.The relative residual rate of pigment in stomach and the facilitation ratio of small intestine were detected in 3 groups and the difference in 3 groups were compared.Results：The relative residual rate of pigment in stomach in Citrate Mosapride group were lower than those in contrast group（P0.05）and had no difference with those in domperidone group（P0.05）.The facilitation ratio of small intestine in Citrate Mosapride group were higher than those in normal control（P0.05）and were better than those in domperidone group（P0.05）.Conclusion： Citrate Mosapride can promote gastric emptying and intestine facilitation in normal mice obviously.It is an ergotrophic drug of the whole gastrointestinal tract.