2型糖尿病患者肺功能改变的临床意义

Clinical study on the changes of pulmonary function of type 2 diabetic patients

目的:观察2型糖尿病(T2DM)患者肺通气功能以及弥散功能的改变情况,分析不同病程、不同并发症对肺功能的影响。方法:对82例T2DM患者及39例健康人进行肺通气功能和弥散功能的测定,进行对比分析。结果:T2DM组,用力肺活量(FVC)、肺总量(TLC)、最大通气量(MVV)、1s用力呼气量(FEV1)占预计值百分比、FEV1/FVC和肺一氧化碳弥散量(DLCO)、单位肺泡容积的一氧化碳弥散量(DLCO/VA)及占预计值百分比均低于对照组(P<0.05)。病程>10年T2DM组VC、FEV1、MVV、TLC、DLCO和DLCO/VA与病程<10年T2DM组比较,差异有统计学意义(P均<0.05)。T2DM有并发症组DLCO和DLCO/VA均明显低于无并发症组(P<0.05)。结论:T2DM患者存在肺通气功能及弥散功能损害,肺弥散功能损害主要与T2DM病程有关,早期监测肺功能指标对T2DM患者肺损伤的预防和治疗有一定意义。

Objective：To evaluate the changes of pulmonary ventilatory function and diffusive function,analysis of different courses,different complications on pulmonary function effect in type 2 diabetic patients（T2DM）.Methods：The Pulmonary ventilation and diffusion capacity of 82 patients with T2DM and 39 healthy objects were measured,the results were compared.Results：The indices of FVC,TLC,MVV,FEV1/FVC,FEV1,DLCO,DLCO/VA in the T2DM patients were significantly lower than those in the control group（P0.05）.VC,FEV1,MVV,TLC,DLCO and DLCO/VA in diabetics with duration of more than 10 years had significant difference compared with that of the diabetics with duration of less than 10 years（P0.05）.The indicies of DLCO and DLCO/VA in T2DM patients with complications were significant lower than those in non-complication group（P0.05）.Conclusion：There are various degrees of disorder in pulmonary ventilatory function and diffusive function of T2DM patients.Early monitoring of ventilation function of the patients would be beneficial for prevention and treatment of pulmonary injury to patients with T2DM.