吡贝地尔治疗帕金森病运动波动的疗效观察

Efficacy of piribedil in treatment of fluctuating Parkinsonian patients.

目的 观察吡贝地尔（ 泰舒达） 治疗帕金森病运动波动的临床疗效。方法 以５０ 例帕金森病运动波动患者治疗前后为自身对照的研究方法，在原治疗基础上每日加用吡贝地尔１００ ～１５０ ｍｇ ，连续观察８ 周。临床疗效按帕金森病改良 Ｗｅｂｓｔｅｒ １０ 大症状评分法为观察指标。结果 吡贝地尔对运动波动的剂末现象、开关现象和痛性痉挛的有效比例分别为１９／２４ 、９／２２ 和３／４ ，总有效率为６２ ％ 。不良反应以恶心呕吐多见。结论 吡贝地尔治疗帕金森病运动波动疗效肯定，口服吗叮啉可使不良反应减轻或缓解。

Objective To observe the clinical effect of Piribedil ( Trastal) in fluctuating Parkinsonian patients.Methods 50 cases of fluctuating Parkinsonian patients were studied with self control method. They were given additional Piribedil 100～150 mg per day for consecutive 8 weeks. The clinical efficacy is evaluted with modified Webster scale. Results The effective proportion of different fluctuating symptoms in end off dose, on off and cramp were 19/24,9/22 and 3/4 respectively.The total effective rate is 62%. Nausea and vomiting were frequent side effects. Conclusions Piribedil has definite efficacy in treatment of fluctuating Parkinsonian patients. The side effects can be rilieved by Motilium(Domperidone).