摘要
为探讨早期发现 Graves 病( 简称 G D) 患者的骨代谢异常,对63 例 G D 患者进行了尿脱氧吡啶啉( Dpd) 、血清骨钙素( B G P) 、碱性磷酸酶( A K P) 、血钙、血磷及腰椎( L2 ~4) 、股骨上端骨密度( B M D) 的测定。结果: G D 组血 B G P、尿 Dpd 均高于正常对照组( P< 0 .05) ;除≤40 岁女性 G D 组的腰椎和股骨上端[ 股骨颈( N E C K) 、华氏三角( W A R D) 及股骨粗隆( T R O C H)] 的 B M D 和> 40 岁女性 G D 组的 W A R D B M D 外,其余各组腰椎及股骨上端的 B M D 均低于正常对照组( P< 0 .05) 。相关性分析: B G P、 Dpd 与 F T4 呈正相关( P< 0 .05) ,与病程无相关性, B G P 与 N E C K、 W A R D 呈负相关( P< 0 .05) 。结果提示: B M D、尿 Dpd 、血清 B G P 的测定可以早期发现 G D 患者的骨代谢异常,较传统方法更加特异和敏感。
In order to learn the changes of bone metabolism in Graves disease early, urinary deoxypyridinoline(Dpd), serum bone GLA protein(BGP), alkaline phosphatase(AKP), serum calcium, phosphorus and bone mineral density of lumbar 2~4 , upper femur of 63 patients with Graves disease were tested. The result showed serum BGP and urinary Dpd were higher than the controls ( P <0.05). BMD of lumbar 2~4 and the upper femur were lower than the controls ( P <0.05) except those female patients younger than forty years old and those of WARD in female patients older than forty years old. The correlation analysis showed that serum BGP and urinary Dpd were positive correlated with FT 4, but not with duration of illness, serum BGP was negative correlated with femur (NECK, WARD′s triangle) ( P < 0.05 ). The results suggested that the test of BMD, urinary Dpd and serum BGP could detect the abnormal changes of bone metabolism in Graves disease, these tests were more specific and sensitive than those traditional methods.
出处
《首都医科大学学报》
CAS
1999年第3期186-188,共3页
Journal of Capital Medical University
关键词
GRAVES病
骨密度
血清
骨钙素
尿脱氧吡啶啉
Graves disease
bone mineral density
serum bone GLA protein
urinary deoxypyridinoline