膀胱癌组织MDR_1基因产物P-GP_(170)表达的意义

The Significance of the MDR 1 Gene Products GP 170 Expression in the Bladder Cancer Tissue

为证实肿瘤多项耐药基因（ Ｍ Ｄ Ｒ１） 产物 Ｐ Ｇ Ｐ１７０ 与膀胱癌化疗失败及复发的关系，利用免疫组化方法对７２例膀胱癌进行了研究。发现膀胱癌术后丝裂霉素膀胱灌注化疗失败者的 Ｐ Ｇ Ｐ１７０ 阳性率及强阳性率均明显高于初发膀胱癌，并且高分级肿瘤的 Ｐ Ｇ Ｐ１７０ 阳性及强阳性表达均高于低分级肿瘤。通过本实验可以认为膀胱癌化疗效果如何与膀胱癌组织中 Ｍ Ｄ Ｒ１ 产物的量有关。

The drug resistance of the tumor cells is the important factor in the failure of chemotherapy for cancer. To demonstrate the relation between the MDR 1 products and the failure of chemotherapy for bladder cancer, the 72 cases of bladder cancer were studied with the immunohistochemical method. The restults suggested that the positive rate and the strong positive rate of the MDR 1 products in the cases , in which the chemotherapy with mitomycin pouring into the bladdler post operation was fail, were higher than those in the initial stage of bladder cancer. The positive and strong positive expressions of MDR 1 products in the high differentiation tumors were higher than those in the low differentiation tumors. This research indicated that the outcome of the chemotherapy for bladder cancer is relevant to the amounts of the MDR 1 products in the bladder cancer tissue.