莫西沙星治疗老年性下呼吸道感染的临床疗效

Efficacy of moxifloxacin in treating elderly lower respiratory tract infection

目的观察莫西沙星与左氧氟沙星治疗老年性下呼吸道感染的临床疗效和安全性。方法选择老年性下呼吸道感染患者74例,随机分为治疗组（38例）和对照组（36例）。治疗组使用莫西沙星400 mg,对照组使用左氧氟沙星500 mg,均为静脉滴注给药,每日1次,疗程7~10 d,观察疗效与不良反应。结果治疗组和对照组的临床有效率分别为92.11%和80.56%,细菌清除率分别为93.33%和82.76%,两组间比较差异均有统计学意义（P〈0.05）,两组间不良反应相似。结论莫西沙星注射液治疗老年性下呼吸道感染疗效佳且安全,优于左氧氟沙星注射液。

Objective To observe the efficacy and safety of moxifloxacin and levofloxacin in the treatment of elderly lower respiratory tract infection.Methods Thirty-eight cases with elderly lower respiratory tract infection were included as treatmet group treated with moxifloxalin（400 mg,iv.qd,7-10 d）and 36 cases as control group with levofloxacin（500 mg,iv.qd,7-10 d）.Results The total clinical effective rates of the treatment group and control group were 92.11% and 80.56%,and the baiterial eradication rates were 93.33% and 82.76%.There were significant differences of the above figures between the two groups.Conclusion Moxifloxacin is more effective and safe than levofloxacin in treating elderly lower respiratory tract infection.