精神分裂症患者认知性电位的检测

Cognitive evoked potentials in patients with schizophrenia

目的 探讨精神分裂症患者认知性电位 (CEP)特征以及治疗缓解后CEP变化。 方法应用美国CA 10 0 0型电生理仪 ,建立光和声 2种成对刺激方法的关联性负变 (CNV)以及声、光、触 3种刺激方法的长潜时电位 (AEP、VEP、SEP) ,对 3 1例精神分裂症患者进行CNV、AEP、VEP和SEP测定 ,并对其中 2 5例患者作了CEP随访。结果 患者组与对照组比较 ,在CNV潜伏期A点及PINV上明显延迟 ,分别为 ( 5 0 4± 163 )、( 3 46± 5 2 )、( 2 66± 173 )、( 198± 5 7)ms(P <0 0 5或P <0 0 1) ,A S2 ’面积明显缩小 ,分别为 ( 971± 2 86)、( 14 5 7± 3 72 ) μV(P <0 0 1)。在AEP、VEP、SEP潜伏期上发现 ,AEP/P2、VEP/P2、SEP/P2前移 (P <0 0 5 ) ,AEP/P1、VEP/N2和SEP/N1也提前 (P <0 0 5 ) ,但AEP/P3延迟 (P <0 0 5 )。波幅变化表明 ,AEP/N1 P2、VEP/N1 P2、VEP/P2以及SEP/P2 N2降低 (P <0 0 5 )。随访提示 ,本组康复时CEP波形较发病期稳定 ,CNV潜伏期A点明显缩短 (P <0 0 5 ) ,波幅B明显增高 (P <0 0 5 ) ,VEP/N1 P2和SEP/P2 N2波幅增高 ,AEP/P2、VEP/P2以及AEP/P1数值恢复至正常 (P <0 0 5 )。结论 4种CEP变化作为本病状态标记 ,其价值值得进一步探讨。

Objective To investigate the features of cognitive evoked potentials (CEPs) in schizophrenics and the changes of CEPs between the duration of episode and remission Methods The present study was made with stimuli of auditory, visual, and somatosensory modalities CEPs were recorded from 31 episodical schizophrenics and 25 of them were retested when their clinical symtoms rempitted Results The episodical patients showed significantly longer A latency ( P <0 05) and PINV latency ( P <0 01), and smaller A S 2' area ( P <0 01) Shorter latency was associated with P2 of auditory evoked potential , visual evoked potential and somatosensory evoked potential ( P <0 05), P1 of AEP, N2 of VEP, and N1 of SEP ( P <0 05) Longer latency was associated with P3 of AEP ( P <0 05) Diminished amplitude was associated with N1 P2 of AEP and N1 P2 of VEP, P2 of VEP, and P2 N2 of SEP ( P <0 05) The follow up study revealed that when the psychiatric symptoms remitted, the waveform of CEPs became more steady; amplitude B of CNV, N1 P2 of VEP and P2 N2 of SEP were increased ( P <0 05); the amplitude P2 of AEP and VEP, and P1of AEP were increased into the normal range Conclusion The variations of CEPs are the state marker of schizophrenia