幽门螺杆菌阳性的十二指肠溃疡病人胃窦炎症程度和炎症因子的分析

Effect of antral gastritis and cytokines on Helicobacter pylori associated duodenal ulcer

目的 研究幽门螺杆菌 (helicobacterpylori,Hp)致十二指肠溃疡时胃窦炎症和炎症因子的作用。方法 选择 4 8例有不同程度Hp感染的十二指肠溃疡病人 ,用组织学方法评定胃窦炎症程度 ,同时测定胃粘膜内白细胞介素 6(IL 6)、白细胞介素 8(IL 8)、肿瘤坏死因子α(TNFα)、过氧化物酶(MPO)和丙二醛 (MDA)的含量。结果 IL 8、TNFα、MPO、MDA的含量均与胃窦粘膜的炎症程度和Hp感染的强度呈正相关 ,IL 8、TNFα、MPO、MDA之间也有明显的相关性 ,而IL 6与它们之间没有相关性。结论 十二指肠溃疡病人中 ,炎症因子可能为联系Hp相关胃炎和十二指肠溃疡的关键因素。

Objective To investigate the role of cytokines and antral gastritis in the development of duodenal ulcer that associated with Helicobacter pylori (H. pylori) infection Method 48 cases of duodenal ulcer with different degrees of H. pylori infection (35 cases with H.pylori infection and 13 patients without H.pylori infection,) were investigated by measuring the level of gastric mucosal cytokines and the degree of antral gastritis Results Compared with H.pylori negative cases, the patients with H.pylori positive duodenal ulcer had higher level of gastric mucosal IL 8,TNFα, MPO, MDA and severer antral gastritis IL 8, TNFα, MPO and MDA were positirely correlated with H. pylori density and they were highly correlated with each other However IL 6 did not have such specific properties Conclusion Cytokines may be an important factor that links gastritis and duodenal ulcer associated with H.pylori infection