摘要
聚乙二醇(PEG)多-肽复合物兼承了PEG良好的理化性质和多肽诸多的生物特性,近年来在药物递释、组织修复、生物改性等生物医学领域备受关注。阐述了以PEG多-肽嵌段共聚物、接枝梳状聚合物及生物缀合物为主的3类PEG多-肽复合物的制备途径,及其应用于生物医学领域(组织工程材料、药物缓控释载体以及生物表面改性)的研究进展。
Exhibiting well combined properties from PEG and peptide, recently, their hybrids have a growing attention in biomedical field such as controlled drug delivery,tissue regeneration and surface modification. A perspective on approaches of integrating the peptides and polyethylene glycol to b/o-hybrid materials of three kinds containing block copolymer,graft polymer and their conjugates are presented. The resulting unique properties of these bio-hybrids in regard to the application in biomedical fields（ tissue engineering ,drug delivery/release system and surface modification） are introduced as well.
出处
《塑料》
CAS
CSCD
北大核心
2011年第1期54-58,共5页
Plastics
关键词
聚乙二醇-多肽复合物
生物材料
生物医学应用
药物缓释
组织工程
表面改性
PEG-peptide hybrids
biomaterial
biomedical application
controlled drug release
tissue engineering
surface modification
