MTX单次与多次给药方式保守治疗异位妊娠比较

MTX single and multiple injection methods of conservative treatment of ectopic pregnancy compared

目的比较不同的氨甲喋呤(MTX)给药方式治疗异位妊娠的疗效及副反应。方法回顾性分析我院2007年1月-2009年9月MTX药物保守治疗异位妊娠患者。其中A组(86例)采用MTX50mg/m2,单次肌注,最多不超过3个疗程。B组(74例)采用MTX-CF(甲酰四氢叶酸)方案:MTX1mg/kg隔日肌注,第1,3,5,7天,CF0.1mg/kg,第2,4,6,8天。两组患者均定期复查血β-HCG、阴超、血常规及肝肾功能,并每日严密观察生命体征、腹痛及阴道流血情况。结果单次给药与多次给药成功率无明显差异,但从两者用药后患者副反应表现来看,单次给药副反应要少。结论单次给药用量少,副反应小,易被患者接受。

Objective： To compare the different methotrexate （MTX） injection methods of treatment of ectopic pregnancy efficacy and side effects.Methods： Retrospective analysis of our hospital in January 2007-2009 year in September of drug MTX in patients with conservative treatment of ectopic pregnancy.Where A （86 cases） using MTX 50mg/m2,a single intramuscular injection,a maximum of 3 courses.B group （74 cases） with MTX-CF （leucovorin） Program： MTX1mg/kg intramuscular injection every other day,the first 1,3,5,7 days,CF 0.1mg/kg,days 2,4,6,8.Two groups of patients were reviewed on a regular basis of blood β-HCG,Yin Chao,blood and liver and kidney functions,and a daily close observation of vital signs,abdominal pain and vaginal bleeding conditions.The results of single dose and multiple dose had no significant difference in success rate,but the two drugs side effects in patients after performance,single-dose fewer side effects.Conclusion： Single-less to the pharmaceutical,side effects is small,easily tolerated.