脑梗死诱发全身炎症反应综合征患者总胆红素、尿酸和超敏C反应蛋白水平变化

Clinical Study of Serum T-BIL,UA,hsCRP in Patients with Systemic Inflammatory Response Syndrome Induced by Acute Cerebral Infarction

目的:探讨血清总胆红素(T-BIL)、尿酸(UA)、超敏C反应蛋白(hsCRP)在急性脑梗死(ACI)诱发全身炎症反应综合征(SIRS)中的作用。方法:应用全自动生化分析仪,分别在发病24h内和第14天测定60例ACI致SIRS患者(SIRS组)、64例急性单纯ACI患者(SACI组)及60名健康体检者(对照组)血清T-BIL、UA、hsCRP含量。结果:SIRS组患者在发病后14d内有7例死亡。发病24h内,SACI组和SIRS组血清UA、hsCRP均升高,治疗后降低(P<0.05),SIRS组升高更明显(P<0.05)。血清T-BIL仅在SIRS组升高,治疗后恢复至正常(P<0.05)。结论:ACI进展为SIRS后,患者T-BIL、UA、hsCRP明显升高,病情缓解后可以减低,可作为诊断和评估病情的一项指标。

Aim：To study the role of total bilirubin（T-BIL）,uric acid（UA）,high sensitivity C-reactive protein （hsCRP） in systemic inflammatory response syndrome（SIRS） induced by acute cerebral infarction （ACI）.Methods：The levels of T-BIL,UA,hsCRP were measured by automatic biochemistry analyzer in 60 ACI cases accompanied with SIRS（SIRS group）,64 cases of acute simple cerebral infarction （SACI group） and 60 normal cases （control group） at time of onset and 14 days after onset. Results：7 SIRS patients died within 14 days after the onset of illness. The serum UA,hsCRP were significantly increased in SACI and SIRS groups within 24 h after the onset,and decreased after therapy（P0.05）. The serum T-BIL increased only in SIRS group,and decreased to normal after therapy（P0.05）. Conclusion：The serum T-BIL,UA,hsCRP level changes can be used as an index for judging the progress of ACI to SIRS.