肠易激综合征重叠功能性消化不良的问卷调查

Questionnaire Analysis of Irritable Bowel Syndrome Overlapping with Functional Dyspepsia

背景:肠易激综合征(IBS)患者常重叠功能性消化不良(FD),但目前国内关于重叠症状对IBS影响的报道并不多见。目的:研究IBS重叠FD患者的胃肠道症状严重程度、生活质量、内脏敏感性和焦虑程度。方法:选取2009年6月～2010年3月上海瑞金医院的71例IBS患者,其中31例重叠FD,并以10名健康志愿者作为正常对照。以问卷调查的形式评估受试者的胃肠道症状评估量表(GSRS)、IBS-生活质量量表(QOL)、内脏敏感指数量表(VSI)和焦虑自评量表(SAS)评分。结果:单纯IBS组和IBS重叠FD组四项量表评分均显著高于正常对照组(P<0.01)。除外VSI评分,IBS重叠FD组其余评分均显著高于单纯IBS组(P<0.05)。亚组分析显示,与单纯IBS-D组相比,IBS-D-FD组的IBS-QOL评分显著升高(P<0.05);IBS-C-FD组GSRS评分、IBS-QOL评分和SAS评分显著高于单纯IBS-D组和单纯IBS-C组(P<0.05)。结论:IBS重叠FD患者较单纯IBS患者的胃肠道症状更严重,生活质量更差,焦虑症状更严重,但两者的内脏敏感性无明显差异。

Background： Irritable bowel syndrome （IBS） overlapping with functional dyspepsia （FD） is quite common, however, studies on the effect of this overlapping on IBS are few. Aims： To investigate the severity of gastrointestinal symptoms, life quality, visceral sensitivity and anxiety in IBS patients overlapping with FD. Methods： Seventy-one IBS patients including 31 patients overlapping with FD at Shanghai Ruijin Hospital from June 2009 to March 2010 were enrolled, 10 healthy volunteers were served as normal controls. Score of gastrointestinal symptom rating scale （GSRS）, IBS-quality of life （QOL）, visceral sensitivity index （VSI） and self-rating anxiety scale （SAS） were estimated by questionnaire. Results： Score of the 4 rating scales in IBS group alone and IBS-FD group were significantly higher than those in normal control group （P〈0.01）. Score of GSRS, IBS-QOL and SAS in IBS-FD group were significantly higher than those in IBS group alone （P〈0.05）, while no significant difference of VSI score was found between the two groups （P〉0.05）. Subgroup analysis showed that IBS-QOL score in IBS-D-FD group was significantly higher than that in IBS-D group alone （P〈0.05）, and score of GSRS, IBS-QOL and SAS in IBS-C-FD group were significantly higher than those in IBS-D group alone and IBS-C group alone （P〈0.05）. Conclusions： IBS-FD patients suffer more gastrointestinal discomforts, have poorer life quality, and are more in anxiety compared with IBS patients alone. However, there is no difference between the two groups in visceral sensitivity.