血清睾酮水平和代谢综合征的关联分析

Association of the serum testosterone level with metabolic syndrome in men

目的:探讨男性血清睾酮水平和代谢综合征(MS)的关联。方法:2008年11月至2009年2月对北京社区1006例30～60岁男性进行调查,分别检测腰围、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇(HDL-C)、血清睾酮等。采用《2007中国成人血脂异常防治指南》推荐的MS诊断标准,分为MS组和非代谢综合征(NMS)两组,比较两组间各项指标水平差异,分析引起MS不同危险因素中血清睾酮水平以及血清睾酮和MS的相关性。结果:两组之间年龄无统计学差异(P>0.05),腰围、收缩压、舒张压、空腹血糖、甘油三酯、HDL-C、血清睾酮比较有显著性差异(P<0.001)。MS成分增多,血清睾酮水平则明显降低(P<0.01)。血清睾酮水平和年龄、腰围、收缩压、甘油三酯呈负相关(P<0.05)。结论:低血清睾酮水平在一定程度上能预示MS的发展。

Objective：To investigate the association of the serum testosterone （T） level with metabolic syndrome （MS）.Methods： We enrolled in this investigation 1 006 men aged 30-60 years in Beijing and obtained the data on their blood pressure （BP）,waist circumference （WC）,fasting blood glucose （FBG）,serum triglycerides （TG）,high density lipoprotein-cholesterol （HDL-C） and serum testosterone （T）.The men were divided into an MS group and a non-MS （NMS） group based on The Chinese Adult Dyslipidemia Prevention Guide 2007.The results were compared and analyzed.Results： There was no statistically significant difference between the ages of the two groups （P 0.05）.Systolic BP （SBP）,diastolic BP （DBP）,WC,FBG and TG were significantly higher,while serum T and HDL-C remarkably lower in the MS than in the NMS group （P 0.001）.The serum T level was markedly decreased with the increase of MS components （P 0.01）.Both Pearson＇s correlation coefficients and multiple linear regression analyses showed that the serum T level was negatively correlated with age,WC,SBP and TG （P0.05）.Conclusion： Low serum T level may predict the development of MS in men.