Pentacam系统与A超角膜测厚仪测量中央角膜厚度的一致性和重复性

Agreement and repeatability of central corneal thickness measurement using the Pentacam and ultrasound pachymetry

目的探讨Pentacam三维眼前节分析诊断系统测量角膜厚度的可重复性，比较其结果与A型超声角膜测厚仪测量结果的一致性。方法112例拟行准分子激光角膜屈光手术的受检者，只选取右眼作为研究对象，分别由两位检查者盲法使用Pentacam系统和A超角膜测厚仪测量中央角膜厚度3次，将结果进行对比分析。角膜厚度值的比较采用配对t检验进行统计学分析；一致性检验采用Bland—Altman法。结果角膜厚度均值分别为Pentacam系统（538．63±31．55）txm，超声测厚仪（541．024-30．45）μm，两者差异具有统计学意义（t=-3．414，P=0．001），两者的差值平均为（-2．394±7．42）μm。两法具有较好的一致性，95％的一致性界限为（-16．93μm，12．15μm）。Pentacam系统与超声测厚仪测量值的组内相关系数分别为0．86和0．88，两种仪器的测量结果都比较稳定、重复性好。结论Pentacam系统与超声测厚法具有较好的一致性，测量结果的重复性也较好，但要注意增加测量次数。（中华眼科杂志，2011，47：142－145）

Objective To compare the agreement and repeatability of the OCULUS Pentacam （a new Seheimpflug-based imaging system） with ultrasound pachymetry in the measurement of central corneal thickness （CCT）. Methods Central corneal thickness was measured in 112 subjects （112 eyes） separately by two examiners, first using the Pentacam instrument, then using an ultrasonic pachymetry. Measurements were repeated 3 times for each pachymetry. Reslflts Mean values of CCT for each instrument were （538.63 -＋ 31.55） ixm and （541.02 -＋ 30.45 ） p,m using the Pentacam and the ultrasonic pachymeter, respectively. The difference is significant between the two instruments （ t = - 3.414, P = 0. 001 ）, the mean value of the difference is （ - 2.39± 7.42 ）μm. The Bland-Altman Plots displayed relatively good agreement （ limits of agreement were - 16. 93 μm to 12. 15 μm ） between the two instruments. The intraelass correlation coefficient （ICC） of the two devices showed high repeatability （Separately O. 86 and 0.88 ）. Conclusions The agreement between the Pentacam instrument and the ultrasonic paehymetry was good, and the repeatability was also good for both instruments independently, however it is needed to increase measure times to improve the repeatability of the Pentaeam which is a promising new instrument for anterior eye evaluation. （Chin J Ophthalmol , 2011,47：142-145）