期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MicroRNAs及其在肝细胞癌中的研究进展

下载PDF
导出
摘要 MicroRNAs（MicroRNAs）是一类长约19-22个核苷酸的非编码小分子RNA,通过对靶基因转录后水平的负性调控,参与细胞生长、组织分化和肿瘤形成等多种生物学过程,其突变、缺失或表达水平的异常与肿瘤发生、发展密切相关。作为一类新的分子靶标,MicroRNAs应用于肿瘤的诊断、治疗和预后判断具有广阔的前景。本文就MicroRNAs及其在肝细胞癌中的最新研究进展作一综述。
作者 徐晓晶 夏景林
机构地区 复旦大学附属中山医院肝癌研究所
出处 《实用肿瘤杂志》 CAS 北大核心 2011年第1期83-87,共5页 Journal of Practical Oncology
关键词 癌 肝细胞 RNA 基因表达调控 靶向治疗
分类号 R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献30

  • 1Lee RC, Feinbaum RL, Ambros V. The C-elegans heterochronic gene LIN-4 encodes small RNAs with antisense complementarity to LIN-14 [ J]. Cell, 1993,75 (5) :843 -854.
  • 2Lee Y, Jeon K, Lee JT, et al. MicroRNA maturation:stepwise processing and subcellular localization [ J ]. EMBO J,2002,21 (17) :4663 -4670.
  • 3Meng F, Wehlbe-Janek H, Henson R,et al. Microma-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular carcinoma [ J ]. Gastroenterology,2007,133 ( 2 ) :647 - 658.
  • 4Marquez RT, Wendlandt E, Galle CS, et al. MicroRNA- 21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappa B signaling [ J ]. Am J Physiol Gastrintest Liver Physiol, 2010,298 (4) : 535 - 541.
  • 5Chang T, Yu D, Lee Y, et al. Widespread MicroRNA repression by Myc contributes to tumorigenesis [ J ]. Nat Genet, 2008,40( 1 ) :43 - 50.
  • 6Taguchi A, Yanagisawa K, Tanaka M, et al. Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster [ J ]. Cancer Res, 2008,68 (14) : 5540 - 5545.
  • 7Galardi S, Mereatelli N, Giorda E, et al. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27 (Kip1) * [J]. J Biol Chem, 2007,282(32) :23716 - 23724.
  • 8Fomari F, Gramantieri L, Ferracin M, et al. Mir-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma [ J ]. Oncogene, 2008, 27(43) :5651 -5661.
  • 9李琼,王阁,王红中,杨志祥,单锦露,陈川,张志敏,许文,王东,李增鹏.MicroRNA在HepG_2肝癌细胞表达差异谱的研究[J].重庆医学,2007,36(20):2024-2025. 被引量：8
  • 10Esau C, Pear M, Davis S,et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting [J]. Cell Metab,2006,3(2) :87 -98.

二级参考文献28

  • 1孙凯,黄晓卉,甄茂川,汪谦.应用液相芯片分析肝细胞癌及癌旁组织小分子RNA表达谱差异[J].中华实验外科杂志,2006,23(8):945-947. 被引量：25
  • 2Toyota M. identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification[J]. Cancer Res. 1999,59 : 2307-2312.
  • 3Mack GS. Epigenetic cancer therapy makes headway[J]. J Natl Cancer Inst. 2006,18:98-105.
  • 4Qiu j. Epigenetics:unfinished symphony[J]. Nature, 2006,441(7090):143-145.
  • 5Eden A. chromosome instability and tumors promoted by DNA hypermethylation[J]. Science,2003,300:455.
  • 6Belinsky SA. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort[J]. Cancer Res, 2006,66(6) : 3338-3344.
  • 7Hutvagner G, Zamore PD. A microRNA in a multipleturnover RNAi enzyme complex [J]. Science,2002, 297 (5589) : 2056-2060.
  • 8Croce CM, Calin GA. miRNAs, cancer, and stem cell division [ J ]. Cell, 2005,122 ( 1 ) : 6-7.
  • 9Lu J. MicroRNA expression profiles classify human cancers[J]. Nature,2005,435(7043):834-838.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs-mieroRNAs with a role in cancer [JJ. Nat Bey Cancer, 2006, 6(4) : 259-269.

共引文献8

实用肿瘤杂志
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部